Volume 8, Issue 1 (Continuous publishing 2022)                   Iran J Neurosurg 2022, 8(1): 0-0 | Back to browse issues page


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1- Orthopedic Research Center, Mazandaran University of Medical Sciences, Sari, Iran
2- Student Research Committee, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
3- Neurosurgery Department, Imam Hospital, Mazandaran University of Medical Sciences, Sari, Iran
4- Department of Radiology, Imam Hospital, Mazandaran University of Medical Sciences, Sari, Iran
5- Azad University (IR) in Oxford, Oxford, UK AND Department of Family Medicine, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran , Mohsen.aarabi@gmail.com
Abstract:   (1031 Views)
Background and Aim: Modic changes are alterations in the spine endplates and subchondral bone shock absorption, seen by magnetic resonance imaging (MRI). No studies have investigated the effect of vitamin D and alendronate as oral drugs on reducing and modifying Modic changes after degenerative spine fusion surgery. This study aimed to evaluate the efficacy of oral vitamin D and alendronate administration in patients with low back pain, and Modic changes undergoing lumbar fusion surgery.
Methods and Materials/Patients: A total of 81 middle age women with a normal range of serum vitamin d were enrolled in three groups who underwent lumbar fusion surgery according to neurosurgical criteria. Group 1 (n=27) received additional oral alendronate, group 2 (n=27) received oral vitamin D for six months postoperatively, and group 3 (n=27) received no drug (except simple analgesics and antibiotics). The patients were followed up with a visual analog scale (VAS) and Oswestry disability index (ODI). MRI was done before and six months after surgery.
Results: There was no significant difference between the three groups in VAS and ODI scores (P=0.416, P=0.601, respectively), but the mean VAS and ODI in all three groups decreased over six months, which was statistically significant (P<0.001). Modic changes in all three groups changed significantly over 6 months (P<0.01). In the vitamin D and alendronate groups, Modic type 3 increased significantly, but Modic type 2 and Modic type 1 decreased significantly in the vitamin d and no medication groups, respectively.
Conclusion: Oral vitamin D administration has a desirable effect not only on clinical outcomes after lumbar spinal fusion surgery because of degenerative surgery but also on vertebral endplate Modic changes compared to oral bisphosphonate.
Article number: 20
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Type of Study: Research | Subject: Spine

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