Iranian Journal of Neurosurgery
مجله جراحی مغز و اعصاب ایران
Iran J Neurosurg
Medical Sciences
http://irjns.org
1
admin
2423-6497
2423-6829
10.32598/irjns
en
jalali
1394
9
1
gregorian
2015
12
1
1
2
online
1
fulltext
en
Comparison of Prooxidant-antioxidant Balance between Patients with High Grade Gliomas (IV) and Control Group
Gamma Knife Radiosurgery
Research
<p style="text-align: justify;">Background & Aim: The most common primary brain tumors of the central nervous system are gliomas. Among a number of different biomolecular events, a strong relation between oxidative stress pathways and the development of this cancer has been proved. Oxidative stress (OS) is the consequence of an imbalance between pro-oxidants and antioxidants towards pro-oxidants. The pro-oxidants cause lipid peroxidation of cell membranes, protein, DNA oxidation and changes in brain cell growth. In this study, the pro-oxidant–antioxidant balance (PAB) was determined in patients with gliomas. Methods & Materials/Patients: Sera of 49 patients with high grade glioma (grade IV WHO) which is called glioblastoma multiform (GBM) and 49 healthy subjects were collected and PAB test was measured. Results: A significant increase of PAB value was observed in patients with GBM (158.10±85.71 HK unit) in comparison to control group (74.54±33.54 HK). Conclusion: The PAB assay showed the oxidative stress in glioblastoma. In further research, this easy elucidation of oxidative stress in these patients can be applied to evaluate the effectiveness of antioxidant therapies in patients with GBM.Keywords: Prooxidant-antioxidant; Balance; High</p>
Prooxidant-antioxidant, Balance, High Grade Gliomas
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http://irjns.org/browse.php?a_code=A-10-100-22&slc_lang=en&sid=1
Elnaz
Farajirad
الناز
فرجی راد
10031947532846002992
10031947532846002992
No
Head of Ghaem Health Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Kazem
Ghaemi
کاظم
قائمی
10031947532846002993
10031947532846002993
No
Associate Professor of Neurosurgery, Head of Neurosurgery Department, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran.
Mehdi
Khajavi
مهدی
خجوی
10031947532846002994
10031947532846002994
No
Resident of Neurosurgery, Neurosurgery Department, Ghaem Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Daryoush
Hamidi Alamdari
داریوش
حمیدی علمداری
10031947532846002995
10031947532846002995
No
Stem Cell and Regenerative Medicine Research Group, Biochemistry & Nutrition Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Mohammad
Hassan Arjmand
محمد
حسن ارجمند
10031947532846002996
10031947532846002996
No
Master of Biochemistry, Surgery Department, Ghaem Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Mohammad
Farajirad
محمد
فرجی راد
10031947532846002997
10031947532846002997
Yes
Professor of Neurosurgery, Head of Neurosurgery Department, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.