en Spine Case report <div style="text-align: justify;"><strong>Background and Importance: </strong>Spondylodiscitis is an inflammatory disease of the body of one or more vertebrae and intervertebral disc. The fungal etiology of this disease is rare, particularly in&nbsp;patients without immunodeficiency. Delay in diagnosis and treatment of this disease can lead to<br> complications and even death.<br> <strong>Case Presentation: </strong>A 63-year-old diabetic female patient, who had a history of spinal surgery and complaining radicular lumbar pain in both lower limbs with a probable diagnosis of spondylodiscitis,&nbsp;underwent partial L2 and complete L3 and L4 corpectomy and fusion. As a result of pathology from tissue biopsy specimen, Aspergillus fungi were observed. There was no evidence of&nbsp;immunodeficiency in the patient. The patient was treated with Itraconazole 100 mg twice a day&nbsp;for two months. Pain, neurological symptom, and laboratory tests improved.<br> <strong>Conclusion: </strong>The debridement surgery coupled with antifungal drugs can lead to the best therapeutic results.</div> spondylodiscitis, aspergillus, vertebral osteomyelitis 155 160 http://irjns.org/browse.php?a_code=A-10-287-1&slc_lang=en&sid=1 Mohsen Aghapoor maghapoor86@gmail.com 10031947532846005297 10031947532846005297 Yes Department of Neurosurgery, Poursina Hospital, Guilan University of Medical Sciences, Rasht, Iran Babak Alijani Alijani drbabakalij@gmail.com 10031947532846005298 10031947532846005298 No Guilan Road Trauma Research Center, Guilan University of Medical Sciences, Rasht, Iran Mahsa Pakseresht-Mogharab * Mahsapaksereshtmogharab@gmail.com 10031947532846005299 10031947532846005299 No Department of Neurosurgery, Poursina Hospital, Guilan University of Medical Sciences, Rasht, Iran