en Gamma Knife Radiosurgery Research <p>Background & Aim: Spinal cord injury (SCI) is one of the worst kinds of traumatic injuries with remarkable social and economic effects on communities.&nbsp;</p> <p>Methods & Materials/Patients: In this prospective randomized clinical trial, 122 patients with traumatic spinal cord injury were admitted to Poursina hospital within 48 hours of injury to compare granulocyte colony stimulating factor (G-CSF) and high-dose methylprednisolone as neuroprotective therapy.</p> <p>Results: In this research, 122 patients were studied out of whom 62 patients were included in the granulociote colony-stimulating factor (G-CSF) group with a mean age of 40.4, and 60 patients in the methylprednisolone group with an average age of 40.10 years. 55 out of 122 patients (45%) were completely paralyzed (Grade AIS:A) and 67 (55%) were with incomplete spinal injury (Grade AIS:B,C,D). The average American spinal injury association (ASIA) sensory scores in the two groups were similarly compared in the same four time intervals, and p values were 0.7, 0.3, 0.2, and 0.1. They were not statistically significant.&nbsp;</p> <p>Conclusion: According to the results, the G-CSF was shown to be beneficial in average ASIA motor and sensory scores in the two groups of male patients at six months of onset of G-CSF treatment (p value=0.04), and average ASIA motor scores improvement in the falls subgroup patients also differed significantly within six months of onset of G-CSF treatment (p value=0.03). A multicentre prospective randomized clinical trial to compare the placebo effect with G-CSF protocol&#39;s treatment, and also assessment of the cost benefits of the common medical treatment versus G-CSF are needed.&nbsp;</p> <p></p> Keywords: Granulocyte, Colony-stimulating, Methylprednisolone, Treatment 11 14 http://irjns.org/browse.php?a_code=A-10-1-1&slc_lang=en&sid=1 Shahrokh Yousefzadeh-Chabok شاهرخ یوسف زاده چابک 10031947532846003080 10031947532846003080 No MD, Professor of Neurosurgery, Guilan Road Trauma Research Center, Guilan University of Medical Sciences, Rasht, Guilan, Iran دانشگاه علوم پزشکی گیلان Babak Alijani بابک علیجانی babakalij@gmail.com 10031947532846003081 10031947532846003081 Yes MD, Associate Professor of Neurosurgery,Guilan Road Trauma Research Center, Guilan University of Medical Sciences, Rasht, Guilan, Iran دانشگاه علوم پزشکی گیلان Mohammadreza Emamhadi محمد رضا امام هادی 10031947532846003082 10031947532846003082 No MD, Associate Professor of Neurosurgery,Guilan Road Trauma Research Center, Guilan University of Medical Sciences, Rasht, Guilan, Iran دانشگاه علوم پزشکی گیلان Hamid Behzadnia حمید بهزادنیا 10031947532846003083 10031947532846003083 No MD, Assistant Professor of Neurosurgery, Guilan Road Trauma Research Center, Guilan University of Medical Sciences, Rasht, Guilan, Iran دانشگاه علوم پزشکی گیلان Siavash Dehghani سیاوش دهقانی 10031947532846003084 10031947532846003084 No MD, Senior Resident of Neurosurgery, Poursina Hospital, Guilan University of Medical Sciences, Rasht, Guilan, Iran دانشگاه علوم پزشکی گیلان Alireza Razzaghi علیرضا رزاقی 10031947532846003085 10031947532846003085 No MSc in Epidemiology, Guilan Road Trauma Research Center, Poursina Hospital, Guilan University of Medical Sciences, Rasht, Guilan, Iran دانشگاه علوم پزشکی گیلان Shabnam Golmohammadi شبنم گل محمدی 10031947532846003086 10031947532846003086 No MD, Senior Resident of Neurosurgery, Poursina Hospital, Guilan University of Medical Sciences, Rasht, Guilan, Iran دانشگاه علوم پزشکی گیلان