en Neurotrauma Research <div style="text-align: justify;"><span style="font-size:12px;"><strong>Background and Aim: </strong>Craniocerebral trauma is one of the vital public health problems and causes elevated intracranial pressure (ICP) and low cerebral perfusion pressure.<br> <strong>Methods and Materials/Patients:</strong> In this work, 15% hyperosmolar solution colloid-mannitol and 3.5% crystalloid-sodium chloride (NaCl) were used simultaneously. Both have the same mechanism of action creating an osmotic gradient between the blood-brain barrier and brain tissue. In a single-center, randomized open clinical study, 35 patients were treated in the intensive care unit (ICU) with isolated traumatic brain injury aged 18 to 65 years with depression of consciousness (4-12 points on the Glasgow coma scale [GCS]), and abnormal computed tomography (CT) data of the head on admission.<br> <strong>Results:</strong> The data demonstrated the positive effect of mannitol 15% + NaCl 3.5% on ICP and cerebral blood flow. At 20-25 minutes after administration of a bolus of mannitol 15% + NaCl 3.5%, ICP decreased (stage 2) below 20 mm Hg, reaching an average of 18.1&plusmn;0.72 mm Hg, which was a 33.2% decrease from baseline.<br> <strong>Conclusion:</strong> Combined use of mannitol 15% + NaCl 3.5% in the treatment of intracranial hypertension (ICH) in patients with isolated craniocerebral 3.5&plusmn;0.2 mL/kg can be recommended in patients with baseline hypovolemia and hyponatremia.</span></div> Mannitol, Hypertonic sodium chloride (NaCl), Intracranial pressure (ICP), Cerebral perfusion pressure, Hyperosmolar therapy, Craniocerebral trauma 196 209 http://irjns.org/browse.php?a_code=A-10-672-1&slc_lang=en&sid=1 Temur Malik Murotov temurmalik_murotov@mail.ru 100319475328460011980 100319475328460011980 Yes Department of Anesthesiology and Resuscitation, Tashkent Medical Academy, Tashkent, Uzbekistan.