Iranian Journal of Neurosurgery

en Serum Superoxide Dismutase as A Biomarker in Severe Traumatic Brain Injury: A Case-Control Study Neurotrauma Research <div style="text-align: justify;">Background and Aim: Traumatic Brain Injury (TBI) is often described as a “hidden epidemic.” Various biochemical markers reflecting cerebral damage can be used to correlate the patient's prognosis and the development of secondary lesions. We studied human Superoxide dismutase (SOD) in the serum to evaluate its role in the outcome of TBI. Methods and Materials/Patients:  This observational study was conducted in patients with severe TBI who presented to a tertiary care hospital in India. A total of 40 patients with severe TBI were enrolled, with 40 healthy people taken as controls. Serum samples were assayed for serum SOD using the ELISA technique. Results:  The most common age group was 28-37 years. Of 40 patients, 28 were male (70%), and 12 were female (30 %). The most common mode of injury was road traffic accident (70%), followed by fall from height (12.5%), physical assault (12.5%) and sports injury (5%). The most common CT finding was intra-cerebral haematoma (55%), followed by sub-arachnoid haemorrhage (SAH) (10 %), skull fracture (10 %), subdural haemorrhage (SDH) (7.5%) and extradural haemorrhage (EDH) (5%). The mean serum SOD value in the severe TBI group was 23.23 U/ml, and in the control group, it was 135.93 U/ml, which was statistically significant. Out of 40 patients, 24 (60%) had a good Glasgow Outcome Scale (GOS) at the time of discharge, and 16(40%) had poor outcomes. There was a significant improvement in outcome after six months compared to GOS at discharge. Conclusion: The results obtained in the study are preliminary, and more extensive prospective studies are needed to reach a definitive conclusion. A handful of studies on protein degradation products are available and need to be more comprehensive. In conclusion, with more extensive studies and continued exploration SOD can become a reliable tool in TBI and can be integrated into standard care protocols.  </div> Traumatic Brain Injury (TBI), SOD (Superoxide dismutase), biomarker, GOS. 188 195 http://irjns.org/browse.php?a_code=A-10-475-2&slc_lang=en&sid=1 Sharad Pandey drsharad23@yahoo.com 100319475328460012370 100319475328460012370 Yes Department of Neurosurgery , A.B.V.I.M.S. and Dr Ram Manohar Lohia Hospital, New Delhi Sourabh Chakraborty csourav33@gmail.com 100319475328460012371 100319475328460012371 No Department of Neurosurgery , A.B.V.I.M.S. and Dr Ram Manohar Lohia Hospital, New Delhi Pankaj Kumar aditya.thewinner@gmail.com 100319475328460012372 100319475328460012372 No Department of Neurosurgery , A.B.V.I.M.S. and Dr Ram Manohar Lohia Hospital, New Delhi Neera Sharma sharma.neera79@gmail.com 100319475328460012373 100319475328460012373 No Department of Biochemistry, A.B.V.I.M.S. and Dr Ram Manohar Lohia Hospital, New Delhi L. N. Gupta drsharad1012@gmail.com 100319475328460012374 100319475328460012374 No Department of Neurosurgery , A.B.V.I.M.S. and Dr Ram Manohar Lohia Hospital, New Delhi Amol Mittal amollucymittal@gmail.com 100319475328460012375 100319475328460012375 No Department of Neurosurgery , A.B.V.I.M.S. and Dr Ram Manohar Lohia Hospital, New Delhi Achal Saxena docachal712@gmail.com 100319475328460012376 100319475328460012376 No Department of Neurosurgery , A.B.V.I.M.S. and Dr Ram Manohar Lohia Hospital, New Delhi