en Gamma Knife Radiosurgery Research <p style="text-align: justify;"><strong>Introduction</strong>: Traumatic brain injury is considered as the major cause of mortality and hospitalization of about ten million people&nbsp;across the globe. Most of these patients are young and active people suffering disabilities. Tranexamic acid therapy is commonly&nbsp;used to reduce blood loss and need for blood transfusions in surgical cases. This study aimed at investigating the effect of tranexamic&nbsp;acid drug in patients with epidural hematoma.</p> <p style="text-align: justify;"><strong>Methods <span dir="RTL">&</span>Materials/Patients<span dir="RTL">:</span></strong> In a clinical trial study, 100 patients with acute epidural hematoma diagnosed with traumatic&nbsp;brain injury were enrolled. The patients in two groups were matched for age and sex. We treated 50 patients with tranexamic acid&nbsp;drug that were compared with 50 patients in the control group. Hematoma size variations (diameter and volume) between the two&nbsp;groups were studied.</p> <p style="text-align: justify;"><strong>Results:</strong> We studied 100 patients with traumatic brain injury with a mean age of 34.2 &plusmn; 7.9. Of the patients, 69% were male, and&nbsp;31% were female. Hematoma occurrence rate was 33%, 39%, and 28% in parietal, frontal, and temporal region, respectively.&nbsp;Hematoma diameter was 3.71 &plusmn; 1.8 mm after treatment with tranexamic acid, and 4.03 &plusmn; 1.6 mm in the control group. There was&nbsp;no statistically significant difference between the two groups. The volume of hematoma was 8.04 &plusmn; 3.2 cc in patients treated with&nbsp;tranexamic acid, and 10.4 &plusmn; 3.7 cc in the control group. There was statistically significant difference between the two groups.</p> <p style="text-align: justify;"><strong>Conclusion:</strong> According to our study, tranexamic acid drug can be effective on bleeding control in patients with acute epidural&nbsp;hematoma. The role of these drugs in elective surgeries has been proven. In cases of brain trauma, they can be useful and improve&nbsp;the prognosis of patients.</p> Tranexamic acid, Acute Epidural Hematoma, Brain Trauma, Cerebral Hemorrhage 8 10 http://irjns.org/browse.php?a_code=A-10-1-3&slc_lang=en&sid=1 Parviz Samadi-Motlagh پرویز صمدی مطلق 10031947532846003134 10031947532846003134 Yes Department of Neurosurgery, Tabriz University of Medical Sciences, Tabriz, East Azerbaijan, Iran Mohammad Shimia محمد شیمیا 10031947532846003135 10031947532846003135 No Department of Neurosurgery, Tabriz University of Medical Sciences, Tabriz, East Azerbaijan, Iran Moslem Shakeri مسلم شاکری 10031947532846003136 10031947532846003136 No Department of Neurosurgery, Tabriz University of Medical Sciences, Tabriz, East Azerbaijan, Iran Azad Mohammadzadeh آزاد محمدزاده 10031947532846003137 10031947532846003137 No Department of Neurosurgery, Tabriz University of Medical Sciences, Tabriz, East Azerbaijan, Iran Firooz Salehpour فیروز صالح پور 10031947532846003138 10031947532846003138 No Department of Neurosurgery, Tabriz University of Medical Sciences, Tabriz, East Azerbaijan, Iran Atta Mahdkhah عطا مهدخواه 10031947532846003139 10031947532846003139 No Department of Neurosurgery, Tabriz University of Medical Sciences, Tabriz, East Azerbaijan, Iran Farhad Mirzaiee فرهاد میرزایی 10031947532846003140 10031947532846003140 No Department of Neurosurgery, Tabriz University of Medical Sciences, Tabriz, East Azerbaijan, Iran