Volume 8 - Continuous publishing                   Iran J Neurosurg 2022, 8 - Continuous publishing: 20-20 | Back to browse issues page

XML Print


1- Spine Fellowship, Orthopedic Research Center, Mazandaran University of Medical Sciences, Sari, Iran
2- Student Research Committee, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
3- Imam Hospital, Mazandaran University of Medical Sciences, Sari, Iran
4- Imam Hospital, Mazandaran University of Medical Scinces, Sari, Iran
5- School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran , Mohsen.aarabi@gmail.com
Abstract:   (223 Views)
Background and Objectives:  Modic changes are alterations in the Spine endplates and subchondral bone signal absorption, which can be seen by MRI. Today, no studies have investigated the effect of vitamin D and alendronate as oral drugs on the reduction and modification of Modic changes after degenerative spine fusion surgery. Aim the study was to Evaluation of the efficacy of oral vitamin D and alendronate administration in patients with low back pain and Modic changes which undergoing lumbar fusion surgery.
Method: 81 middle age women with normal range of serum Vitamin D had enrolled in three groups who underwent lumbar fusion surgery according to neurosurgical criteria.   Group 1 (n = 27) received additional oral alendronate, Group 2 (n=27) received oral vitamin D for six months postoperatively, and whereas group 3 (n = 27) received no drug (except simple analgesics and antibiotics).patients follow with visual analog scale (VAS) and oswestry disability index (ODI), also MRI has done before and six month after surgery.
Results: There was no significant difference in VAS and ODI between the three groups (P-value = 0.416, P-value = 0.601, respectively) but the mean VAS and ODI in all three groups decreased over six months, which was statistically significant (P-value < 0.001). MODIC change in all three groups changed significantly over 6 months (P-value < 0.01,). In the Vitamin D and Alendronate groups, MODIC 3 increased significantly, but MODIC 2 and MODIC 1 decreased significantly in the Vitamin D and No medication groups, respectively.
Conclusion: it is supposed to oral vitamin D administration has an acceptable effects not only on clinical outcome after lumbar spinal fusion surgery because of degenerative surgery, but also has a good effect on vertebral endplate modic change compared oral bisphosphonate.
 
     
Type of Study: Research | Subject: Spine

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.