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Volume 8, Issue 1 (Continuous publishing 2022)
Iran J Neurosurg 2022, 8(1): 0-0 |
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Ahmadi S A Y, Nourmohammadi M J, Sayahi A, Alijani B, Yousefzadeh-Chabok S, Rezaian J. Effect of Granulocyte Colony-Stimulating Factor (G-CSF) on Improving Impairment Scale After Acute Spinal Cord Injury: An Individual Participant Data Meta-Analysis. Iran J Neurosurg 2022; 8 (1) : 15
URL: http://irjns.org/article-1-322-en.html
URL: http://irjns.org/article-1-322-en.html
Seyyed Amir Yasin Ahmadi1 
, Mohammad Javad Nourmohammadi2 , Ahmed Sayahi2 , Babak Alijani3 , Shahrokh Yousefzadeh-Chabok3 , Jafar Rezaian * 4
, Mohammad Javad Nourmohammadi2 , Ahmed Sayahi2 , Babak Alijani3 , Shahrokh Yousefzadeh-Chabok3 , Jafar Rezaian * 4
1- Neuroscience Research Center, Iran University of Medical Sciences, Tehran, Iran
2- Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran
3- Guilan Road Trauma Research Center, Guilan University of Medical Sciences, Rasht, Iran and Department of Neurosurgery, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
4- Department of Anatomical Sciences, Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran , jafarrezaian@gmail.com
2- Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran
3- Guilan Road Trauma Research Center, Guilan University of Medical Sciences, Rasht, Iran and Department of Neurosurgery, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
4- Department of Anatomical Sciences, Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran , jafarrezaian@gmail.com
Abstract: (805 Views)
Background and Aim: The present study was conducted to investigate the effects of granulocyte
colony-stimulating factor (G-CSF) after acute spinal cord injury on increasing a grade of improvement
entitled American spinal cord injury association impairment scale (AIS) as an individual participant
data (IPD) meta-regression analysis of clinical trials.
Methods and Materials/Patients: According to our search strategy, four studies were selected.
Multilevel ordered logistic regression modeling was used to predict AIS grade with G-CSF
administration and time variable (first day and a 3-month follow-up). The IDs of the studies as well
as the time series variable were imported to the random part of the model. Odds ratio (OR) and
95% confidence interval (CI) were reported.
Results: A total of 277 samples were studied. A fixed effect model was performed at first.
Accordingly, using G-CSF was associated with increased AIS grade (lower impairment) (OR=1.503,
95% CI=1.110-2.035) adjusted with time series (OR=1.868, 95% CI=1.378-2.532). In the mixed
effect model, G-CSF was again associated with increased AIS grade (OR=1.780, 95% CI=1.301-
2.436) adjusted with time series (OR=2.152, 95% CI=1.406-3.294).
Conclusion: The present meta-analysis showed the protective effect of GCS-F observed as an
improvement in AIS grade. This protecting effect was further after adjusting the random effects
of time series and individual studies. Although multilevel modeling could reduce our limitations,
it should be regarded that the number of trials was not enough to establish strong conclusions.
colony-stimulating factor (G-CSF) after acute spinal cord injury on increasing a grade of improvement
entitled American spinal cord injury association impairment scale (AIS) as an individual participant
data (IPD) meta-regression analysis of clinical trials.
Methods and Materials/Patients: According to our search strategy, four studies were selected.
Multilevel ordered logistic regression modeling was used to predict AIS grade with G-CSF
administration and time variable (first day and a 3-month follow-up). The IDs of the studies as well
as the time series variable were imported to the random part of the model. Odds ratio (OR) and
95% confidence interval (CI) were reported.
Results: A total of 277 samples were studied. A fixed effect model was performed at first.
Accordingly, using G-CSF was associated with increased AIS grade (lower impairment) (OR=1.503,
95% CI=1.110-2.035) adjusted with time series (OR=1.868, 95% CI=1.378-2.532). In the mixed
effect model, G-CSF was again associated with increased AIS grade (OR=1.780, 95% CI=1.301-
2.436) adjusted with time series (OR=2.152, 95% CI=1.406-3.294).
Conclusion: The present meta-analysis showed the protective effect of GCS-F observed as an
improvement in AIS grade. This protecting effect was further after adjusting the random effects
of time series and individual studies. Although multilevel modeling could reduce our limitations,
it should be regarded that the number of trials was not enough to establish strong conclusions.
Article number: 15
Keywords: Spinal cord injury, Methylprednisolone, Meta-analysis, Multilevel analysis, Statistical models, Evidence-based medicine
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Articles Copyright © The Author(s).
Owned by Guilan University of Medical Sciences.
Co-published by Negah Institute for Scientific Communication.
Contact Information:
IrJNS Office, Guilan Road Trauma Research Center, Poursina Hospital, Namjoo St, Rasht, Guilan, Iran.
Publisher Tel : +9821 45355555 , 45355000
Email: ir.journalofneurosurgery@gmail.com, info@irjns.org
Owned by Guilan University of Medical Sciences.
Co-published by Negah Institute for Scientific Communication.
Contact Information:
IrJNS Office, Guilan Road Trauma Research Center, Poursina Hospital, Namjoo St, Rasht, Guilan, Iran.
Publisher Tel : +9821 45355555 , 45355000
Email: ir.journalofneurosurgery@gmail.com, info@irjns.org
