Iranian Journal of Neurosurgery
مجله جراحی مغز و اعصاب ایران
Iran J Neurosurg
Medical Sciences
http://irjns.org
1
admin
2423-6497
2423-6829
10.32598/irjns
en
jalali
1399
10
1
gregorian
2021
1
1
7
1
online
1
fulltext
en
Outcomes of Surgical Decompression for Spinal Metastases From Gynecological Cancers: A Retrospective Cohort Study
Spine
Research
<strong>Background and Aim</strong>: Gynecological cancer is one of the most common types of cancer worldwide. Nonetheless, spinal metastasis from gynecological cancer is scarcely reported in the literature. In cases of spinal cord compression, the standard treatment is a decompressive surgery followed by radiotherapy treatment for selected patients. This study aimed to report the overall survival and surgical results in patients presenting with gynecological spinal metastases who underwent spinal cord/nerve root decompression and stabilization.<br>
<strong>Methods and Materials/Patients</strong>: A total of 18 patients were included in this study. The surgical procedures were performed from 2012 to 2019. The evaluation of neurological status, spinal stability, and pain were performed using the American Spinal Injury Association Impairment Scale (ASIA), Spinal Instability Neoplastic Score (SINS), and Visual Analogue Scale (VAS), respectively.<br>
<strong>Results</strong>: The lumbar spine was the most affected location (n=30; 50.0%). Regarding the preoperative neurological deficits, 16 cases (n=16; 88.9%) presented ASIA graded A–D before the surgery, being reduced to five (n=5; 27.8%) after the procedures. The pain level means (pre-and postoperative) were 9.39±0.79 and 2.28±1.44. The overall median survival was 6.1 months (95% Confidence Interval [CI] of 1.10–11.13 months). The mean survival of ambulatory and non-ambulatory patients before the surgery was 7.36 months and 3.2 months, respectively (P=0.007 – Log-rank Mantel–Cox).<br>
<strong>Conclusion</strong>: Decompressive surgery and stabilization promote mechanical pain relief, spinal stability, an improvement of neurological function, and indirectly improving quality of life, despite a dismal overall survival of patients who present with metastatic spinal compression disease.
Female genital neoplasms, Neoplasm metastasis, Spinal cord compression, Epidural neoplasms
37
48
http://irjns.org/browse.php?a_code=A-10-407-1&slc_lang=en&sid=1
Luiz Alves
Vieira Netto
netto261@gmail.com
10031947532846006411
10031947532846006411
No
Faculty of Medicine, Federal University of Goiás, Goiânia, Brazil.
Luís Felipe
Araújo Peres
luis_fel10@hotmail.com
10031947532846006412
10031947532846006412
No
Faculty of Medicine, Federal University of Goiás, Goiânia, Brazil.
Nayara
Matos Pereira
naymp_naymp@hotmail.com
10031947532846006413
10031947532846006413
No
Department of Neurological Surgery, Clinics Hospital of the Faculty of Medicine, Federal University of Goiás, Goiânia, Brazil.
Alice
Jardim Zaccariotti
alicejz@hotmail.com
10031947532846006414
10031947532846006414
No
Faculty of Medicine, Federal University of Goiás, Goiânia, Brazil.
Vladimir
Arruda Zaccariotti
zaccariotti@hotmail.com
10031947532846006415
10031947532846006415
No
Department of Neurological Surgery, Clinics Hospital of the Faculty of Medicine, Federal University of Goiás, Goiânia, Brazil.
Romulo Alberto
Silva Marques
romulo.alberto@icloud.com
10031947532846006416
10031947532846006416
No
Department of Neurological Surgery, Clinics Hospital of the Faculty of Medicine, Federal University of Goiás, Goiânia, Brazil.
João
Batista Arruda
arrudajb@msn.com
10031947532846006417
10031947532846006417
No
Department of Neurological Surgery, Clinics Hospital of the Faculty of Medicine, Federal University of Goiás, Goiânia, Brazil.
Edésio
Martins
prof.edesio@gmail.com
10031947532846006418
10031947532846006418
No
Faculty of Medicine, Federal University of Goiás, Goiânia, Brazil.
Rodrigo Alves
de Carvalho Cavalcante2
drigocavalcante@yahoo.com.br
10031947532846006419
10031947532846006419
Yes
Department of Neurological Surgery, Clinics Hospital of the Faculty of Medicine, Federal University of Goiás, Goiânia, Brazil.