Iranian Journal of Neurosurgery
مجله جراحی مغز و اعصاب ایران
Iran J Neurosurg
Medical Sciences
http://irjns.org
1
admin
2423-6497
2423-6829
10.32598/irjns
en
jalali
1395
3
1
gregorian
2016
6
1
2
1
online
1
fulltext
en
A Comparison between Therapeutic Effect of Granulocyte Colony-stimulating Factor and Methylprednisolone in Treatment of Patients with Acute Traumatic Spinal Cord Injury
Gamma Knife Radiosurgery
Research
<p>Background & Aim: Spinal cord injury (SCI) is one of the worst kinds of traumatic injuries with remarkable social and economic effects on communities. </p>
<p>Methods & Materials/Patients: In this prospective randomized clinical trial, 122 patients with traumatic spinal cord injury were admitted to Poursina hospital within 48 hours of injury to compare granulocyte colony stimulating factor (G-CSF) and high-dose methylprednisolone as neuroprotective therapy.</p>
<p>Results: In this research, 122 patients were studied out of whom 62 patients were included in the granulociote colony-stimulating factor (G-CSF) group with a mean age of 40.4, and 60 patients in the methylprednisolone group with an average age of 40.10 years. 55 out of 122 patients (45%) were completely paralyzed (Grade AIS:A) and 67 (55%) were with incomplete spinal injury (Grade AIS:B,C,D). The average American spinal injury association (ASIA) sensory scores in the two groups were similarly compared in the same four time intervals, and p values were 0.7, 0.3, 0.2, and 0.1. They were not statistically significant. </p>
<p>Conclusion: According to the results, the G-CSF was shown to be beneficial in average ASIA motor and sensory scores in the two groups of male patients at six months of onset of G-CSF treatment (p value=0.04), and average ASIA motor scores improvement in the falls subgroup patients also differed significantly within six months of onset of G-CSF treatment (p value=0.03). A multicentre prospective randomized clinical trial to compare the placebo effect with G-CSF protocol's treatment, and also assessment of the cost benefits of the common medical treatment versus G-CSF are needed. </p>
<p></p>
Keywords: Granulocyte, Colony-stimulating, Methylprednisolone, Treatment
11
14
http://irjns.org/browse.php?a_code=A-10-1-1&slc_lang=en&sid=1
Shahrokh
Yousefzadeh-Chabok
شاهرخ
یوسف زاده چابک
10031947532846003080
10031947532846003080
No
MD, Professor of Neurosurgery, Guilan Road Trauma Research Center, Guilan University of Medical Sciences, Rasht, Guilan, Iran
دانشگاه علوم پزشکی گیلان
Babak
Alijani
بابک
علیجانی
babakalij@gmail.com
10031947532846003081
10031947532846003081
Yes
MD, Associate Professor of Neurosurgery,Guilan Road Trauma Research Center, Guilan University of Medical Sciences, Rasht, Guilan, Iran
دانشگاه علوم پزشکی گیلان
Mohammadreza
Emamhadi
محمد رضا
امام هادی
10031947532846003082
10031947532846003082
No
MD, Associate Professor of Neurosurgery,Guilan Road Trauma Research Center, Guilan University of Medical Sciences, Rasht, Guilan, Iran
دانشگاه علوم پزشکی گیلان
Hamid
Behzadnia
حمید
بهزادنیا
10031947532846003083
10031947532846003083
No
MD, Assistant Professor of Neurosurgery, Guilan Road Trauma Research Center, Guilan University of Medical Sciences, Rasht, Guilan, Iran
دانشگاه علوم پزشکی گیلان
Siavash
Dehghani
سیاوش
دهقانی
10031947532846003084
10031947532846003084
No
MD, Senior Resident of Neurosurgery, Poursina Hospital, Guilan University of Medical Sciences, Rasht, Guilan, Iran
دانشگاه علوم پزشکی گیلان
Alireza
Razzaghi
علیرضا
رزاقی
10031947532846003085
10031947532846003085
No
MSc in Epidemiology, Guilan Road Trauma Research Center, Poursina Hospital, Guilan University of Medical Sciences, Rasht, Guilan, Iran
دانشگاه علوم پزشکی گیلان
Shabnam
Golmohammadi
شبنم
گل محمدی
10031947532846003086
10031947532846003086
No
MD, Senior Resident of Neurosurgery, Poursina Hospital, Guilan University of Medical Sciences, Rasht, Guilan, Iran
دانشگاه علوم پزشکی گیلان