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:: Volume 1, Number 1 (6-2015) ::
IrJNS 2015, 1(1): 10-22 Back to browse issues page
Prognostic Serum Factors in Traumatic Brian Injury: A Systematic Review
Firooz Salehpoor, Ali Meshkini, Ghaffar Shokouhi, Javad Aghazade, Iraj Lotfinia, Moslem Shakeri, Mohammad Shimia, Alireza Razzaghi, Farhad Mirzaee, Atta Mahdkhah *1
1- , mahdkhah@yahoo.com
Abstract:   (955 Views)

Background & Aim: Traumatic brain injury is one of the main causes of death and disability. The aim of this study is to systematically review the articles which assessed some serum factors of traumatic brain injury patients in relation to their outcomes.

Methods & Materials/Patients: Databases were searched for relevant publications from 2005 to 2014. Selection criteria were:Studies which evaluate the factors affecting the outcome after TBI, TBI defined as “acute changes in brain function resulting in a strong external force to the head”.Resultswere measured by Glasgow Outcome Score or a comparable measure.Factors were measured in first month after injury and the prognosis was addressed. All papers were checked and approved by a specialist and expert in that field. A systematic review was performed for prognostic factors. Results: Sixty-three studies were included. Most studies used Glasgow Outcome Score at 6 months post-injury as outcome measure, sometimes in combination with other outcome measures. Strong evidence for predicting outcome was found for serum concentration of S100 protein, NSE, MBP, NF-H, GFAP, UCH-L1, blood glucose levels, serum levels of LDH, sodium level, prothrombin time, partial thromboplastin time, platelet count, D.dimer, HSP 70, serum levels of IL-8, number of circulating EPCs, and  DNA levels in serum. Moderate evidence for predicting outcome was found for high serum MMP9. Strong evidence of no association was found for WBC count and serum cortisol levels. Moderate evidence of no association was found for serum total cholesterol for other determinants, inconclusive or no evidence or limited evidence was found.

Conclusion: S100 protein, NSE, MBP, NF-H, GFAP, UCH-L1, blood glucose levels, serum levels of LDH, sodium level, prothrombin time, Partial thromboplastin time, platelet count, D.dimer, HSP 70, serum levels of IL-8, number of circulating EPCs, and  DNA levels in serum predicted outcome after traumatic brain injury. WBC count, serum cortisol levels, total cholesterol and MMP9 did not have predictive value.

Keywords: Prognostic, Serum Factors, Traumatic Brain Injury
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Type of Study: Research | Subject: Special
* Corresponding Author Address: * Correspondence: Department of Neurosurgery, Tabriz University of Medical Sciences, East Azarbaijan, Iran Tel:+989144039122, Fax:+04133340830,
References
1. Goyal A, Carter M, Niyonkuru C, Fabio A, Amin K, Berger RP, Wagner AK M D. S100b as a Prognostic Biomarker in Outcome Prediction for Patients with Severe TBI. J Neurotrauma. 2013;30(11):946-57.
2. Mowery NT. Stress Insulin Resistance is a Marker for Mortality in Traumatic Brain Injury. J Trauma. 2009:66(1):145-51; 151-3.
3. CampelloYurgel V, Ikuta N, Brondani da Rocha A, Lunge VR, Fett Schneider R, Kazantzi Fonseca AS, et al. Role of Plasma DNA as a Predictive Marker of Fatal Outcome following Severe Head Injury in Males. J Neurotrauma. 2007;24(7):1172–81. Available from: http:// dx.doi.org/10.1089/neu.2006.0160
4. Ali E. Seif El-Deen, Said Hammad. Preoperative Serum S100 B Protein as a Prognostic Marker for Traumatic Brain Injury Patients. E.J.N.S. 2009;24 (1)135-152.
5. DeFazio MV, Rammo RA, Robles JR, Bramlett HM, Dietrich WD, Bullock MR. The Potential Utility of Blood- Derived Biochemical Markers as Indicators of Early Clinical Trends Following Severe Traumatic Brain Injury. World Neurosurgery. 2014;81(1):151–8. Available from: http://dx.doi.org/10.1016/j.wneu.2013.01.015
6. Beers SR, Berger RP, Adelson PD. Neurocognitive outcome and serum biomarkers in inflicted versus non-inflicted traumatic brain injury in young children. J Neurotrauma. 2007;24(1):97-105.
7. A.Salim. Persistent Hyperglycemia in Severe Traumatic Brain Injury: An Independent Predictor of Outcome. Am Surg. 2009;75(1):25-9
8. Gopcevic A. Plasma interleukin-8 as a potential predictor of mortality in adult patients with severe traumatic brain injury. Tohoku J Exp Med. 2007;211(4):387-93.
9. Liu L, Wei H, Chen F, Wang J, Dong JF, Zhang J. Endothelial progenitor cells correlate with clinical outcome of traumatic brain injury. Crit Care Med. 2011;39(7):1760- 5.
10. Bayir A, Kalkan E, Kocak S, Ak A, Cander B, Bodur S. Fibrinolytic markers and neurologic outcome in traumatic brain injury. Neurol India.2006;54:363-5.
11. Copin H.Matrix metalloproteinase 9 and cellular fibronectin plasma concentrations are predictors of the composite endpoint of length of stay and death in the intensive care unit after severe traumatic brain injury. Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine.2012;43(6): 23-27.
12. Meshkini A,Salehpour F. Relationships of hyperglycemia and neurological outcome in patients with head injury.Anesthesia.2007;43(2): 2-6.
13. Douglas D. Fraser. Severe traumatic brain injury in children elevates glial fibrillary acidic protein in cerebrospinal fluid and serum. Pediatr Crit Care Med.2011;32(6):33-36.
14. Choon Hong Kan, MohdSaffari, TeikHooiKhoo. Prognostic Factors of Severe Traumatic Brain Injury Outcome in Children Aged 2-16 Years at A Major Neurosurgical Referral Centre. Malaysian Journal of Medical Sciences.2009;16(4):25-33.
15. SalehpoorF, Meshkini A. Prognostic value of serum LDH in head trauma. The International Medical Journal. 2005;4(2)31-37.
16. Meier R. Differential temporal profile of lowered blood glucose levels (3.5 to 6.5 mmol/l versus 5 to 8 mmol/l) in patients with severe traumatic brain injury. Crit Care.2008;12(4):98-102.
17. Hohl E. Plasma levels of oxidative stress biomarkers and hospital mortality in severe head injury: A multivariate analysis. Journal of Critical Care 27, 523. e11–523.e19;2012.
18. Liliang PC. Tau Proteins in Serum Predict Outcome After Severe Traumatic Brain Injury.Journal of Surgical Research. 2010;160(5):302–307.
19. Hossam M, Jehan H. Sabry, Deena A. El-Shabrawy. The Predictability of at Admission Serum GFAP and S100 protein Levels for the Outcome of Traumatic Brain Injury Patients. Egy. J. Neur. Surg. 2011;26(1):50-56.
20. Gullo J da S, Bertotti MM, Silva CCP, Schwarzbold M, Diaz AP, Soares FMS, et al. Hospital Mortality of Patients with Severe Traumatic Brain Injury is Associated with Serum PTX3 Levels. Neurocrit Care. 2010; 23;14(2):194–9. Available from: http://dx.doi. org/10.1007/s12028-010-9462-y.
21. Greuters. Acute and delayed mild coagulopathy are related to outcome in patients with isolated traumatic. brain injury.Crit Care.2011;15(1):2.
22. StefaniaM. Neuronal and glial markers are differently associated with computed tomography findings and outcome in patients with severe traumatic brain injury: a case control study. Critical Care.2012;15(1):156-159.
23. Guzel A.Serum neuron-specific enolase as a predictor of short-term outcome and its correlation with Glasgow Coma Scale in traumatic brain injury.Neurosurg Rev.2008; 31:439–445.
24. Zitnay GA, Zitnay KM, Povlishock JT, Hall ED, Marion DW, Trudel T, et al. Traumatic Brain Injury Research Priorities: The Conemaugh International Brain Injury Symposium. Journal of Neurotrauma 2008;25(10):1135–52. Available from: http://dx.doi. org/10.1089/neu.2008.0599
25. Hada M. Role of early cell-free DNA levels decrease as a predictive marker of fatal outcome after severe traumatic brain injury. ClinicaChimica Acta.2012; 414: 12–17.
26. Lanier WL, StanglandKJ ,Scheithaure BW. The effects of dextrose infusion and head position on neurologic outcome after complete cerebral ischemia in primates: examination of a model. Anesthesiology.1987;66:39-48.
27. Chabok SY, Moghadam AD, Saneei Z, Amlashi FG, Leili EK, Amiri ZM. Neuron-specific enolase and S100BB as outcome predictors in severe diffuse axonal injury. Journal of Trauma and Acute Care Surgery. 2012;72(6):1654–7. Available from: http://dx.doi. org/10.1097/ta.0b013e318246887e
28. Pelinka LE, Kroepfl A, Leixnering M, Buchinger W, Raabe A, Redl H. GFAP Versus S100B in Serum after Traumatic Brain Injury: Relationship to Brain Damage and Outcome. J Neurotrauma. 2004; 21(11):1553–61. Available from: http:// dx.doi.org/10.1089/0897715042441846
29. Smith A.Relationship between hyperglycemia and outcome in children with severe traumatic brain injury. PediatrCrit Care Med.2012;13(1):85-91.
30. Lin C, Huang SJ, Wang N, Shen ZP. Relationship between plasma leptin levels and clinical outcomes. Peptides. 2012 Jun 30;35(2):166-71.
31. Turgeon AF, Lauzier F, Burns KEA, Meade MO, Scales DC, Zarychanski R. Determination of neurological prognosis in adult patients with severe traumatic brain injury: a survey of Canadian intensivists, neurosurgeons and neurologists. Crit Care Med ,epub ahead of print; 2013 .
32. HergenroederG.W. Serum IL-6: a candidate biomarker for intracranial pressure elevation following isolated traumatic brain injury. Journal of Neuroinflammation.2010;3:7-19.
33. Jeremitsky E. The Impact of Hyperglycemia on Patients with Severe Brain Injury. J Trauma. Jan.2005;58(1):31-36.
34. Liu D.Clinical Impact of Early Hyperglycemia during Acute Phase of Traumatic Brain Injury.Neurocrit Care.2009;11:151–157.
35. Donald E. G. Griesdale, Marie-He´le`ne Tremblay, Jonathan McEwen, Dean R. Chittock. Glucose Control and Mortality in Patients with Severe Traumatic Brain Injury. Neurocrit Care.2009;11:311–316.
36. Llompart-Pou JA. Relationship between plasma adrenocorticotropin hormone and intensive care unit survival in early traumatic brain injury. J Trauma.2007;62(6):1457-61.
37. Tude M. Mortality in Children with Severe Head Trauma: Predictive Factors and Proposal for a New Predictive Scale. Neurosurgery.2010;67(6):1542-7.
38. Hossam M, Jehan H. Sabry, Deena A. El-Shabrawy. The Predictability of at Admission Serum GFAP and S100 protein Levels for the Outcome of Traumatic Brain Injury Patients. Egy. J. Neur. Surg.2011;26(1);11-19.
39. Matsushima K, Peng M, Velasco C, Schaefer E, Diaz- Arrastia R, Frankel H. Glucose variability negatively impacts long-term functional outcome in patients with traumatic brain injury. J Crit Care.2012;27(2):125-31.
40. Žurek J, Bartlová L, Fedora M. Hyperphosphorylatedneurofilament NF-H as a predictor of mortality after brain injury in children. Brain InjInforma Healthcare; 2011;25(2):221–6. Available from: http:// dx.doi.org/10.3109/02699052.2010.541895
41. Amy K., Wagner. Acute Serum Hormone Levels: Characterization and Prognosis after Severe Traumatic Brain Injury. J Neurotrauma.2011;28(6): 871–888.
42. Olivecrona M, Rodling-Wahlstrom M, Naredi S, Koskinen L-OD. S-100B and neuron specific enolase are poor outcome predictors in severe traumatic brain injury treated by an intracranial pressure targeted therapy. Journal of Neurology, Neurosurgery & Psychiatry. BMJ;2009;80(11):1241–8. Available from: http://dx.doi. org/10.1136/jnnp.2008.158196
43. SaadatS. Association of persistent hyperglycemia with outcome of severe traumatic brain injury in pediatric population. Childs Nerv Syst.2012; 28:1773–1777.
44. Naeimi ZS, Weinhofer A, Sarahrudi K, Heinz T, Vécsei V. Predictive value of S-100B protein and neuron specific-enolase as markers of traumatic brain damage in clinical use. Brain Inj. Informa UK Limited; 2006;20(5):463–8. Available from: http://dx.doi. org/10.1080/02699050600664418
45. CzeiterR. Brain Injury Biomarkers May Improve the Predictive Power of the IMPACT Outcome Calculator. Journal of Neurotrauma.2012; 29:1770–1778 .
46. Nazik A, Fatih T, Muhammet Ş. Admission hyperglycemia is a reliable outcome predictor in children with severe traumatic brain injury. J Pediatr (Rio J).2011;87(4):325-8.
47. Salim A. Significance of Troponin Elevation after Severe Traumatic Brain Injury. J Trauma.2008; 64(1):46- 52.
48. Nelson DW, Rudehill A, MacCallum RM, Holst A, Wanecek M, Weitzberg E, et al. Multivariate Outcome Prediction in Traumatic Brain Injury with Focus on Laboratory Values. Journal of Neurotrauma. 2012;29(17):2613–24. Available from: http://dx.doi. org/10.1089/neu.2012.2468
49. Perel P, Wasserberg J, Ravi RR, Shakur H, Edwards P, Roberts I. Prognosis following head injury: a survey of doctors from developing and developed countries. J EvalClin Pract2007;13:464-0005.
50. Melo JR. Acute hyperglycemia is a reliable outcome predictor in children with severe traumatic brain injury. ActaNeurochir (Wien).2010; 152(9):1559-65.
51. Rachel P. Berger, Ronald L. Hayes, Rudolph Richichi, Sue R. Beers. Serum Concentrations of Ubiquitin C-Terminal Hydrolase-L1 and αII-Spectrin Breakdown Product 145kDa Correlate with Outcome after Pediatric TBI. J Neurotrauma.2012; 29(1): 162–167.
52. Samit M. Biochemical Serum Markers in Head Injury, Clinical Neurosurgery.2012;57:134-140.
53. Tude M. Defenestration in children younger than 6 years old: mortality predictors in severe head trauma. Childs Nerv Syst.2009; 25:1077–1083.
54. Mondello E. Clinical Utility of Serum Levels of Ubiquitin C-Terminal Hydrolase as a Biomarker for Severe Traumatic Brain Injury. Neurosurgery.2012;70(3):666-75.
55. Nyle K. Increased serum-GFAP in patients with severe traumatic brain injury is related to outcome. Journal of the Neurological Sciences.2006; 240: 85 – 91.
56. Mc Gonzalez-Mao. Model Predicting Survival / ExitusAfter Traumatic Brain Injury: Biomarker S100B 24H. Clin. Lab.2011; 57:587-597.
57. Soares L. Interleukin-10 Is an Independent Biomarker of Severe Traumatic Brain Injury Prognosis. Neuroimmunomodulation. 2012;19:377–385.
58. Salehpour F, Bazzazi AM, Porhomayon J, NaderND. Correlation between coagulopathy and outcome in severe head trauma in neurointensive care and trauma units. J Crit Care.2011;26(4):352-6.
59. Stein DM. Relationship of Serum and Cerebrospinal Fluid Biomarkers With Intracranial Hypertension and Cerebral Hypoperfusion After Severe Traumatic Brain Injury. J Trauma.2011;70(5):1096-103.
60. Nelson DW. Hierarchical log linear analysis of admission blood parameters and clinical outcome following traumatic brain injury. J Neurotrauma.2012;29(17):2613-24.
61. NyleN. Serum levels of S100B, S100A1B and S100BB are all related to outcome after severe traumatic brain injury. ActaNeurochir (Wien).2008;150(3):221-7.
62. Raineya T, Leskob M. Predicting outcome after severe traumatic brain injury using the serum S100B biomarker: Results using a single (24 h) time-point. Resuscitation.2009; 341–345.
63. ŽurekJ ,Fedora M. The usefulness of S100B, NSE, GFAP, NF-H, secretagogin and Hsp70 as a predictive biomarker of outcome in children with traumatic brain injury. Acta Neurochir.2012; 154:93–103.
64. Els C.H. Prognosis of six-month function after traumatic brain injury.Rehabil Med.2010; 42: 425–436.
65. V. Jain, S. Tiwari, S. Misra, Tiwari, Nagendra. Predictive Value of Serum Lactate Dehydrogenase in Head Injury. The Internet Journal of Surgery. 2010; 22(2):101-110.
66. Barlow P, Teasdale G. Prediction of outcome and the management of severe head injuries: the attitudes of neurosurgeons. Neurosurg.1986; 19:989-991.
67. Gong D, Hao M, Liu L, Liu C, Dong J, Cui Z, et al. Prognostic relevance of circulating endothelial progenitor cells for severe traumatic brain injury. Brain Inj. Informa Healthcare. 2012;26(3):291–7. Available from: http:// dx.doi.org/10.3109/02699052.2011.648710
68. Oliviera D. Plasma von Willebrand Factor Levels Correlate with Clinical Outcome of Severe Traumatic Brain Injury. Journal of neurotrauma.2007; 24:1331– 1338.
69. Papa L. Serum levels of ubiquitin C-terminal hydrolase distinguish mild traumatic brain injury from trauma controls and are elevated in mild and moderate traumatic brain injury patients with intracranial lesions and neurosurgical intervention. J Trauma Acute Care Surg.2012; 72(5):1335-44.
70. WhaSookSeo, HyunSoo Oh. Comparisons of Acute Physiological Parameters Influencing Outcome in Patients with Traumatic Brain Injury and Hemorrhagic Stroke. Worldviews Evid Based Nurs.6(1):36-43;2009.
71. Prisco L, Iscra F, Ganau M, Berlot G.Early predictive factors on mortality in head injured patients: a retrospective analysis of 112 traumatic brain injured patients. J Neurosurg Sci. 2012 Jun;56(2):131-6.
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DOI: 10.18869/acadpub.irjns.1.1.10


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Salehpoor F, Meshkini A, Shokouhi G, Aghazade J, Lotfinia I, Shakeri M, et al . Prognostic Serum Factors in Traumatic Brian Injury: A Systematic Review. IrJNS. 2015; 1 (1) :10-22
URL: http://irjns.org/article-1-1-en.html
Volume 1, Number 1 (6-2015) Back to browse issues page
مجله جراحی مغز و اعصاب ایران Iranian Journal of Neurosurgery
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