Volume 5, Issue 2 (Spring 2019)                   Iran J Neurosurg 2019, 5(2): 6-7 | Back to browse issues page

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Rezvani M, Tabesh H, Adimi M, Alavi M, Zareian A, Rahiminejad M et al . The Effect of Intravenous Tranexamic Acid Before and During Spinal Surgery in Bleeding Volume ‎During and After Surgical Operation. Iran J Neurosurg. 2019; 5 (2) :6-7
URL: http://irjns.org/article-1-121-en.html
1- Medical School of Isfahan University of Medical Sciences, Isfahan, Iran
2- Medical School of Isfahan University of Medical Sciences, Isfahan, Iran , meisammeisami04@gmail.com
Abstract:   (204 Views)
Background: Bleeding during surgery is one of the well-known surgical complications. In this study, we decided to determine the effect of TA in reducing blood loss in patients undergoing spinal surgeries.
Methods: In a clinical trial study, 100 patients, undergoing spinal surgeries, were divided in two random groups. One group receiving TA and the other selected as the control group. Patients in the treatment group received 1 gram of intravenous TA and another 250 milligram intravenously, one hour after the beginning of the surgery. Bleeding during the surgery, in the first 24 hours and the first 48 hours were recorded separately. Transfusion necessity and its volume, as well as number of hospital admission days were compared in the two groups.
Results: Bleeding during surgery in TA group was significantly lower than the control group (433 ml versus 522 ml respectively, P-value = 0.009). Also, after surgery, during the first 24 hours, bleeding in TA group was significantly less than the control group (P-value = 0.011). During the second 24 hours after surgery bleeding was similar between the two groups (P-value = 0.112). The values of hemoglobin in both groups slowly decreased and the trend of decrease was not significantly different between TA group and the control group (P-value = 0.154).
Conclusions: In spinal surgeries, TA administration in the beginning of the process, reduces surgical bleeding during surgery and in the first 24 hours after surgery. Transfusion requirements, reduction in hemoglobin level, duration of operation and length of hospital stay were independent of TA administration in this study. Considering the possible complications, TA administration is suggested for patients with less than 12 grams of hemoglobin per deciliter. Future studies are needed to conclude the advantageous and disadvantageous effects of TA administration in spinal surgeries
Type of Study: Clinical Trial | Subject: Spine

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