Volume 5, Issue 3 (Summer 2019)                   Iran J Neurosurg 2019, 5(3): 10-15 | Back to browse issues page

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Masoudi M S, Hadi N, Ghaffarpasand F, Askarpour M, Ershadi F, Sadeghpour T. Risk Factors of Neural Tube Defects in a Sample of ‎Iranian Population from Southern Iran; a Hospital-‎Based Investigation. Iran J Neurosurg. 2019; 5 (3) :10-15
URL: http://irjns.org/article-1-160-en.html
1- Department of Neurosurgery – Shiraz University of Medical Sciences, Shiraz, ‎Iran ‎
2- Department of Community Medicine – Shiraz University of Medical Sciences, ‎Shiraz, Iran ‎
3- Research Center for Neuromodulation and Pain, Shiraz, Iran‎ , fariborz.ghaffarpasand@gmail.com
4- Student Research Committee – Department of Community Medicine – Shiraz ‎University of Medical Sciences, Shiraz, Iran ‎
5- Department of Pediatric Neurosurgery – Namazi hospital, Shiraz, Iran‎
Abstract:   (94 Views)

Purpose: The risk factors of the neural tube defects (NTD) have been previously described but there are ethnic and geographical variations. Data from Iranian population is still scarce. The aim of the current study was to determine the NTDs risk Factors in a large sample of Iranian patients admitted to a single center.

Methods: This case-controlled study was conducted during a 5-year period from 2012 to 2017 in Namazi hospital of Shiraz, a tertiary healthcare center referral for all the neonatal anomalies in southern Iran. We included a total number of 100 newborns and child with NTDs as the case group and 200 healthy newborns as the control group. We recorded the baseline characteristics including the maternal variables (age, weight, height, previous pregnancy and gravid, gestational age), newborn information (birth weight, clinical diagnosis, clinical finding in examination, clinical finding in radiologic test) and medical history of the perinatal period.

Results: The demographic findings of mothers were match together. In our study 66% of mothers in case vs. 78% of mothers in control group were taken adequate folic acid during pregnancy (p = 0.030; OR 95% CI = 1.82). Also taking folic acid before pregnancy was significantly different between two groups (p= 0.002 OR 95% CI= 2.36). The prevalence of neural tube defects was significantly higher in patients who living in hot climates (p= 0.001).

Conclusion: Finally, we concluded that taking adequate folic acid supplement before and during pregnancy can reduce and hot climate zone can increase the risk of NTDs.

Type of Study: Research | Subject: Basic Neurosurgery

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