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Hoseinpourfard M, Nasehi M, Zarrindast M, Izadi M, Nami M. Evaluation of Pain Tolerance Threshold Following Administration of Anti-TNF-α in REM Sleep-deprived Male Wistar Rats. Iran J Neurosurg 2021; 7 (4) :185-190
URL: http://irjns.org/article-1-278-en.html

Background and Aim: The level of Tumor Necrosis Factor-alpha (TNF-α) changes by REM sleep deprivation. TNF-α is a known biomarker of REM sleep deprivation (RSD). Prior studies have shown that any alteration in REM sleep can increase the amount of TNF-α. Accordingly, the Pain Tolerance Threshold (PTT) is believed to be increased in patients with insomnia after using anti-TNF-α or Infliximab (IFX). The present study aims to demonstrate the effect of IFX and its importance in the pain management of hospital inpatients.

Methods and Materials/Patients: Seventy-two male Wistar rats in 9 groups were studied after obtaining the approval of the ethics committee of Tehran University of Medical Sciences (CNS.Protocol-ICSS-940816). Remicade was used for inducing the anti-TNF-α. Multiple platform water-tank was used for REM sleep deprivation induction. Pain tolerance was measured on a hot plate apparatus.
Results: There was a significant increase in the duration of the rats’ tolerance on the hot plate between the saline group and the group that received IFX (0.2 mg/kg) (F2 = 8.363) (P = <0.001).