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Iran J Neurosurg 2023, 9 - Continuous Publishing: 0-0 |
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Saiedi E, Mahmoud-Nejad S, Mohazzab-Torabi S, Ganjeifar B. Concurrent Neurological Involvement in Chronic Lymphocytic Leukemia: A Rare Case with Brain and Spinal Manifestations. Iran J Neurosurg 2023; 9 : 28
URL: http://irjns.org/article-1-357-en.html
URL: http://irjns.org/article-1-357-en.html
1- Department of Neurosurgery, Mashhad University of Medical Sciences, Iran
2- Department of Neurosurgery, Mashhad University of Medical Sciences, Iran , smntrb@gmail.com
2- Department of Neurosurgery, Mashhad University of Medical Sciences, Iran , smntrb@gmail.com
Abstract: (715 Views)
Background and importance: Chronic lymphocytic leukemia (CLL) is the most common lymphoproliferative disorder in the United States. CLL invasion to the central nervous system (CNS) is a scarce complication followed by diverse outcomes. Moreover, symptomatic CNS lesion as the primary clinical presentation of undiagnosed CLL is extremely rare. In CNS involvements, it usually invades leptomeningeal, and less commonly causes parenchymal lesions.
Case Presentation: We introduce 71 years 71-year-old man with a history of CLL referred to our center with headache and lower extremities weakness CNS involvement. After the initial evaluation, the MRI findings revealed a “ring or target sign” both in the temporal lobe and intramedullary spinal cord according to T9-T10. Surgical resection of the temporal lesion was done and CLL was confirmed with histological findings.
Conclusion: Finally, the primary presentation of CLL with CNS involvement is an uncommon occurrence. It doesn't show a preference for age, gender, or ethnicity and can occur at any stage of CLL. Therefore, it is important to be aware of this possibility when patients with a history of CLL present with neurological symptoms
Case Presentation: We introduce 71 years 71-year-old man with a history of CLL referred to our center with headache and lower extremities weakness CNS involvement. After the initial evaluation, the MRI findings revealed a “ring or target sign” both in the temporal lobe and intramedullary spinal cord according to T9-T10. Surgical resection of the temporal lesion was done and CLL was confirmed with histological findings.
Conclusion: Finally, the primary presentation of CLL with CNS involvement is an uncommon occurrence. It doesn't show a preference for age, gender, or ethnicity and can occur at any stage of CLL. Therefore, it is important to be aware of this possibility when patients with a history of CLL present with neurological symptoms
Article number: 28
Type of Study: Case report |
Subject:
Brain Tumors
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Owned by Guilan University of Medical Sciences.
Co-published by Negah Institute for Scientific Communication.
Contact Information:
IrJNS Office, Guilan Road Trauma Research Center, Poursina Hospital, Namjoo St, Rasht, Guilan, Iran.
Publisher Tel : +9821 45355555 , 45355000
Email: ir.journalofneurosurgery@gmail.com, info@irjns.org
Owned by Guilan University of Medical Sciences.
Co-published by Negah Institute for Scientific Communication.
Contact Information:
IrJNS Office, Guilan Road Trauma Research Center, Poursina Hospital, Namjoo St, Rasht, Guilan, Iran.
Publisher Tel : +9821 45355555 , 45355000
Email: ir.journalofneurosurgery@gmail.com, info@irjns.org
