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Iran J Neurosurg 2024, 10 - Continuous Publishing: 0-0 |
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Murotov T M. Effect of hyperosmolar combined solution of mannitol 15% plus 3.5% NaCl solution on cerebral edema in patients with traumatic brain injury. Iran J Neurosurg 2024; 10 : 23
URL: http://irjns.org/article-1-412-en.html
URL: http://irjns.org/article-1-412-en.html
Associate Professor, Department of Anesthesiology and Resuscitation of the Tashkent Medical Academy, Tashkent, Republic of Uzbekistan , temurmalik_murotov@mail.ru
Abstract: (292 Views)
Abstract: Craniocerebral trauma remains one of the most important public health problems and causes elevated intracranial pressure and low cerebral perfusion pressure. Background: in this work, we used both hyperosmolar solution colloid-mannitol 15% and crystalloid-NaCl 3.5% at the same time. Both have the same mechanism of action creating an osmotic gradient between the blood-brain barrier and brain tissue. Material and methods: retrospective - 15 patients and prospective - 20 patients, single-center, randomized open clinical study of 35 patients, who were treated in the intensive care unit (ICU) №1 and №2 with isolated traumatic brain injury at the age of 18 to 65 years with depression of consciousness (4-12 points on the Glasgow Coma Scale (GCS)), and abnormal computed tomography (CT) data of the head on admission. Results: the presented data demonstrate the positive effect of mannitol 15% + NaCl 3.5% on ICP and cerebral blood flow. At 20-25 minutes after administration of a bolus of mannitol 15% + NaCl 3.5%, ICP decreased (stage 2) below 20 mmHg, reaching an average of 18.1±0.72 mmHg, decreasing relative to baseline by 33.2%. Conclusions: combined use of mannitol 15% + NaCl 3.5% in the treatment of intracranial hypertension in patients with isolated craniocerebral 3.5±0.2 ml/kg can be recommended in patients with baseline hypovolemia and hyponatremia.
Article number: 23
Keywords: Mannitol, hypertonic sodium chloride, intracranial pressure, cerebral perfusion pressure, hyperosmolar therapy, craniocerebral trauma
Type of Study: Research |
Subject:
Neurotrauma
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This is an open access article distributed under the terms of the Creative Commons Attribution License (CC-By-NC), which permits use, distribution, and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
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