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Volume 10 - Continuous Publishing
Iran J Neurosurg 2024, 10 - Continuous Publishing: 0-0 |
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Pandey S, Chakraborty S, Kumar P, Sharma N, Gupta L N, Mittal A et al . Serum Superoxide Dismutase as A Biomarker in Severe Traumatic Brain Injury: A Case-Control Study. Iran J Neurosurg 2024; 10 : 22
URL: http://irjns.org/article-1-419-en.html
URL: http://irjns.org/article-1-419-en.html
Sharad Pandey * 
1, Sourabh Chakraborty2 , Pankaj Kumar2 , Neera Sharma3 , L. N. Gupta2 , Amol Mittal2 , Achal Saxena2
1, Sourabh Chakraborty2 , Pankaj Kumar2 , Neera Sharma3 , L. N. Gupta2 , Amol Mittal2 , Achal Saxena2
1- Department of Neurosurgery , A.B.V.I.M.S. and Dr Ram Manohar Lohia Hospital, New Delhi , drsharad23@yahoo.com
2- Department of Neurosurgery , A.B.V.I.M.S. and Dr Ram Manohar Lohia Hospital, New Delhi
3- Department of Biochemistry, A.B.V.I.M.S. and Dr Ram Manohar Lohia Hospital, New Delhi
2- Department of Neurosurgery , A.B.V.I.M.S. and Dr Ram Manohar Lohia Hospital, New Delhi
3- Department of Biochemistry, A.B.V.I.M.S. and Dr Ram Manohar Lohia Hospital, New Delhi
Abstract: (128 Views)
Background and Aim: Traumatic Brain Injury (TBI) is often described as a “hidden epidemic.” Various biochemical markers reflecting cerebral damage can be used to correlate the patient's prognosis and the development of secondary lesions. We studied human Superoxide dismutase (SOD) in the serum to evaluate its role in the outcome of TBI.
Methods and Materials/Patients:
This observational study was conducted in patients with severe TBI who presented to a tertiary care hospital in India. A total of 40 patients with severe TBI were enrolled, with 40 healthy people taken as controls. Serum samples were assayed for serum SOD using the ELISA technique.
Results:
The most common age group was 28-37 years. Of 40 patients, 28 were male (70%), and 12 were female (30 %). The most common mode of injury was road traffic accident (70%), followed by fall from height (12.5%), physical assault (12.5%) and sports injury (5%). The most common CT finding was intra-cerebral haematoma (55%), followed by sub-arachnoid haemorrhage (SAH) (10 %), skull fracture (10 %), subdural haemorrhage (SDH) (7.5%) and extradural haemorrhage (EDH) (5%). The mean serum SOD value in the severe TBI group was 23.23 U/ml, and in the control group, it was 135.93 U/ml, which was statistically significant. Out of 40 patients, 24 (60%) had a good Glasgow Outcome Scale (GOS) at the time of discharge, and 16(40%) had poor outcomes. There was a significant improvement in outcome after six months compared to GOS at discharge.
Conclusion:
The results obtained in the study are preliminary, and more extensive prospective studies are needed to reach a definitive conclusion. A handful of studies on protein degradation products are available and need to be more comprehensive. In conclusion, with more extensive studies and continued exploration SOD can become a reliable tool in TBI and can be integrated into standard care protocols.
Methods and Materials/Patients:
This observational study was conducted in patients with severe TBI who presented to a tertiary care hospital in India. A total of 40 patients with severe TBI were enrolled, with 40 healthy people taken as controls. Serum samples were assayed for serum SOD using the ELISA technique.
Results:
The most common age group was 28-37 years. Of 40 patients, 28 were male (70%), and 12 were female (30 %). The most common mode of injury was road traffic accident (70%), followed by fall from height (12.5%), physical assault (12.5%) and sports injury (5%). The most common CT finding was intra-cerebral haematoma (55%), followed by sub-arachnoid haemorrhage (SAH) (10 %), skull fracture (10 %), subdural haemorrhage (SDH) (7.5%) and extradural haemorrhage (EDH) (5%). The mean serum SOD value in the severe TBI group was 23.23 U/ml, and in the control group, it was 135.93 U/ml, which was statistically significant. Out of 40 patients, 24 (60%) had a good Glasgow Outcome Scale (GOS) at the time of discharge, and 16(40%) had poor outcomes. There was a significant improvement in outcome after six months compared to GOS at discharge.
Conclusion:
The results obtained in the study are preliminary, and more extensive prospective studies are needed to reach a definitive conclusion. A handful of studies on protein degradation products are available and need to be more comprehensive. In conclusion, with more extensive studies and continued exploration SOD can become a reliable tool in TBI and can be integrated into standard care protocols.
Article number: 22
Type of Study: Research |
Subject:
Neurotrauma
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This is an open access article distributed under the terms of the Creative Commons Attribution License (CC-By-NC), which permits use, distribution, and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
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