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Iran J Neurosurg 2026, 12 - Contnious Publishing: 0-0 |
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Hatami R, Norollahi S E, Ashraf A, Abedi Z, Karimiyan P, Yousefzadeh S, et al . Association Between Peripheral Blood Cell Parameters and Survival in Patients With Glioblastoma Undergoing Surgery. Iran J Neurosurg 2026; 12 : 8
URL: http://irjns.org/article-1-559-en.html
URL: http://irjns.org/article-1-559-en.html
Reza Hatami1 
, Seyedeh Elham Norollahi2 , Ali Ashraf3 , Zahra Abedi4 , Paridokht Karimiyan5 , Shahrokh Yousefzadeh6 , Fatemeh Afshar7 , Delaram Nazari8 , Ali Akbar Samadani *9
, Seyedeh Elham Norollahi2 , Ali Ashraf3 , Zahra Abedi4 , Paridokht Karimiyan5 , Shahrokh Yousefzadeh6 , Fatemeh Afshar7 , Delaram Nazari8 , Ali Akbar Samadani *9
1- School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
2- Reproductive Health Research Center, Al-Zahra Hospital, Guilan University of Medical Sciences, Rasht, Iran.
3- Clinical Research Development Unit, Poursina Hospital, Guilan University of Medical Sciences, Rasht, Iran.
4- Department of Molecular Genetics, To.C., Islamic Azad University, Tonekabon, Iran.
5- Department of Pathology, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
6- Guilan Road Trauma Research Center, Trauma Institute, Guilan University of Medical Sciences, Rasht, Iran.
7- School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
8- School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
9- Guilan Road Trauma Research Center, Trauma Institute, Guilan University of Medical Sciences, Rasht, Iran & Medical Biotechnology Research Center, School of Paramedicine, Guilan University of Medical Sciences, Rasht, Iran. ,a.a.hormoz@gmail.com
2- Reproductive Health Research Center, Al-Zahra Hospital, Guilan University of Medical Sciences, Rasht, Iran.
3- Clinical Research Development Unit, Poursina Hospital, Guilan University of Medical Sciences, Rasht, Iran.
4- Department of Molecular Genetics, To.C., Islamic Azad University, Tonekabon, Iran.
5- Department of Pathology, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
6- Guilan Road Trauma Research Center, Trauma Institute, Guilan University of Medical Sciences, Rasht, Iran.
7- School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
8- School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
9- Guilan Road Trauma Research Center, Trauma Institute, Guilan University of Medical Sciences, Rasht, Iran & Medical Biotechnology Research Center, School of Paramedicine, Guilan University of Medical Sciences, Rasht, Iran. ,
Abstract: (14 Views)
Background and Aim: Glioblastoma (GBM) is the most aggressive primary malignancy of the central nervous system and continues to be associated with dismal survival outcomes despite advances in surgical and adjuvant therapies. In recent years, systemic inflammation has emerged as a potential contributor to tumor progression, prompting growing interest in readily accessible blood-based biomarkers. Among these, the neutrophil-to-lymphocyte ratio (NLR) and platelet-tolymphocyte ratio (PLR) have been proposed as simple and cost-effective prognostic indicators; however, their clinical utility in GBM remains uncertain.
Methods and Materials/Patients: This observational cohort study included 71 adult patients with histologically confirmed GBM. Pre-treatment hematological parameters were obtained within 24 hours before surgery, including leukocyte subsets and platelet counts, from which NLR and PLR were calculated. Overall survival (OS) was evaluated over a six-month follow-up period. Survival distributions were estimated using the Kaplan–Meier method, and associations between variables and survival were assessed using Cox proportional hazards models.
Results: At baseline, patients exhibited a systemic inflammatory profile, reflected by elevated median NLR and PLR values. During follow-up, 39.4% of patients died, with a median OS of 180 days. Despite this inflammatory pattern, neither NLR nor PLR was significantly associated with OS in either univariable or multivariable analyses. Similarly, no meaningful relationships were observed between survival and other hematological parameters or baseline clinical characteristics, including age, sex, and comorbidities.
Methods and Materials/Patients: This observational cohort study included 71 adult patients with histologically confirmed GBM. Pre-treatment hematological parameters were obtained within 24 hours before surgery, including leukocyte subsets and platelet counts, from which NLR and PLR were calculated. Overall survival (OS) was evaluated over a six-month follow-up period. Survival distributions were estimated using the Kaplan–Meier method, and associations between variables and survival were assessed using Cox proportional hazards models.
Results: At baseline, patients exhibited a systemic inflammatory profile, reflected by elevated median NLR and PLR values. During follow-up, 39.4% of patients died, with a median OS of 180 days. Despite this inflammatory pattern, neither NLR nor PLR was significantly associated with OS in either univariable or multivariable analyses. Similarly, no meaningful relationships were observed between survival and other hematological parameters or baseline clinical characteristics, including age, sex, and comorbidities.
Article number: 8
Type of Study: Research |
Subject:
Brain Tumors
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This is an open access article distributed under the terms of the Creative Commons Attribution License (CC-By-NC), which permits use, distribution, and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
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