Volume 1, Issue 4 (3-2016)                   Iran J Neurosurg 2016, 1(4): 29-30 | Back to browse issues page

XML Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Ahmadvand H, Ahmadi S A Y, Sayahi A, Rezaian J. Role of Apoptosis in CNS Emphasizing Spinal Cord Injuries: A Commentary. Iran J Neurosurg. 2016; 1 (4) :29-30
URL: http://irjns.org/article-1-57-en.html
1- Professor of Biochemistry, Lorestan University of Medical Sciences, Khorramabad, Iran
2- Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran
3- Assistant Professor of Neuroanatomy, Research Office for the History of Persian Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran
Abstract:   (1787 Views)

Apoptosis is a kind of programmed cell death that is naturally necessary for homeostasis and some processes like organogenesis and implantation of embryo; so it is not pathologic and harmful all the time. The purpose of this commentary was to describe the ways of stimulating and inhibiting the apoptosis process; because rather in the therapeutic protocols we should stimulate or inhibit the process in order to minimize the effects of the traumas and injuries. For using the first results in therapeutic protocols; for example, in order to take action against tumors, we should stimulate apoptosis with chemotherapeutic drugs or other alternatives. On the contrary, in physical traumas of spinal cord, we should inhibit apoptosis with chemical drugs or other alternatives in order to reduce secondary paralysis and other side effects. By collecting the present results and comparing them with our previous original articles, we reached some ideas for the future original research and therapeutic proposals.

Full Text [PDF 163 kb]   (516 Downloads) |   |   Full Text (HTML)  (204 Views)  

1. Montazeri F, Rahgozar S, Ghaedi K. Apoptosis and cytosolic organelles. Genetics in the 3rd Millennium. 2011;9(1):2300-2312.
2. Khalatbary A, Tiraihi T, Beigi Boroujeni M, Ahmadvand H, Tavafi M, Tamjidipoor A. Study of Neuroprotective Effects of Green Tea Antioxidant on Spinal Cord Injury of Rat. Journal of Iranian Anatomical Sciences. 2010;7(28-29):145-52.
3. Hashemi M, Ghavami S. Methods of Studying the Apoptosis. Journal of Rafsanjan University of Medical Sciences. 2008;7(1):71-78.
4. Stark AM, Hugo HH, Tscheslog H, Mehdorn HM. p53, BCL-2 and BAX in non-small cell lung cancer brain metastases: acomparison of real-time RT-PCR, ELISA and immunohistochemical techniques. Neurological research. 2007;29(5):435-40. [DOI:10.1179/016164107X165282] [PMID]
5. Taati M, Moghadasi M, Dezfoulian O, Asadian P, Zendehdel M. Effects of Ghrelin on germ cell apoptosis and proinflammatory cytokines production in Ischemia-reperfusion of the rat testis. Iranian journal of reproductive medicine. 2015;13(2):85. [PMID] [PMCID]
6. Zendedel A, Delavari S, Ahmadvand H, Ghanadi K, Gholami M. Effects of Selenium on Antioxidant Activity and Recovery From Sciatic Nerve Ischemia–Reperfusion in Adult Rats. Zahedan Journal of Research in Medical Sciences. 2015;17(12).
7. Kumar Jaganathan S, Balaji A, Vignesh Vellayappan M, Kumar Asokan M, Priyadharshni Subramanian A, Aruna John A, et al. A review on antiproliferative and apoptotic activities of natural honey. Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry-Anti-Cancer Agents). 2015;15(1):48-56.
8. Khalatbary AR, Ahmadvand H. Anti-inflammatory effect of the epigallocatechin gallate following spinal cord trauma in rat. Iranian biomedical journal. 2011;15(1/2):31. [PMID] [PMCID]
9. Ahmadvand H, Tavafi M. Amelioration of Glomerulosclerosis by Satureja khozestanica Essential Oil in Alloxan-Induced Diabetic Rats. ZJRMS. 2014;16(10):23-6.
10. Pourkhodadad S, Alirezaei M, Moghaddasi M, Ahmadvand H, Karami M, Delfan B, et al. Neuroprotective effects of oleuropein against cognitive dysfunction induced by colchicine in hippocampal CA1 area in rats. The Journal of Physiological Sciences. 2016:1-9. [DOI:10.1007/s12576-016-0437-4]
11. Khalatbary AR, Ahmadvand H. Neuroprotective effect of oleuropein following spinal cord injury in rats. Neurological research. 2012;34(1):44-51. [DOI:10.1179/1743132811Y.0000000058] [PMID]
12. Khalatbary AR, Ahmadvand H. Effect of oleuropein on tissue myeloperoxidase activity in experimental spinal cord trauma. Iranian biomedical journal. 2011;15(4):164. [PMID] [PMCID]

Add your comments about this article : Your username or Email:

© 2019 All Rights Reserved | Iranian Journal of Neurosurgery

Designed & Developed by : Yektaweb