Volume 1, Issue 2 (12-2015)                   Iran J Neurosurg 2015, 1(2): 17-21 | Back to browse issues page

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Meshkini A, Salehpour F, Pourhajshokr N, Samadi Mothagh P, Ghojazadeh M. Effect of Intravenous Injection of Erythropoietinon Hospitalization Period in Patients with Acute Spinal Cord Trauma. Iran J Neurosurg. 2015; 1 (2) :17-21
URL: http://irjns.org/article-1-10-en.html
Abstract:   (1572 Views)

Background & Aim: Spinal cord injury (SCI) has a very long history, and its cases form a large proportion of patients admitted to trauma centers in Iran. Studies show that repair after spinal cord injury can be done. In fact, many pharmaceutical agents, such as erythropoietin (EPO), are applied to reduce secondary injury following the initial disorder and to maintain the nerve tissue. Methods & Materials/Patients: In this clinical trial, 60 patients with acute spinal cord injury classified as A to C according to Frankel classification grading system were selected and matched with regard to the Frankel classes, the cervical and dorsal levels and then divided into two groups A and B (each containing 30 patients). Group A, in addition to receive conventional treatment, took EPO and was evaluated in terms of hospitalization period outcomes (mean length of stay, lower extremity thrombosis, intubation, bedsores) and was compared with group B (receiving conventional medicines, such as methylprednisolone). Results: Of the 60 patients, 15 patients were female and 45 were male, with the age range of 19-72 years. The mean length of stay in the case and control group was 10.6±6.52 and 13.8±10.37 days, respectively. Six patients died during hospitalization, including three patients in the case group and three patients in the control group. 12 patients were intubated during this period, including five patients in the case group and seven patients in the control group. Of the 29 patients with bedsores, 14 patients were in the case group and 15 patients were in the control group. None of the patients had lower extremity venous thrombosis during hospitalization. Conclusion: No significant difference was found between the case and control group in the hospital stay length, intubation, bedsores and lower extremities venous thrombosis.

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Type of Study: Research | Subject: Gamma Knife Radiosurgery
* Corresponding Author Address: Corresponding Author: Neuroscience Research Center (NSRC), Department of Neurosurgery, Imam Reza Hospital, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, East Azarbaijan, Iran. Tel:+98413340830, Fax:+98413340830, Email: meshkinia@yaho

1. Wilson JR, Cho N, Fehlings MG. Acute Traumatic Spinal Cord Injury: Epidemiology, Evaluation, and Management. Spine Surgery Basics: Springer; 2014. p. 399-409.
2. Eltoray E. Principles of Spine Surgery2009.
3. Vaccaro AR. Fractures of the cervical, thoracic, and lumbar spine: CRC Press; 2002. [DOI:10.1201/b14040]
4. Hall ED, Springer JE. Neuroprotection and acute spinal cord injury: a reappraisal. NeuroRx. 2004;1(1):80-100. [DOI:10.1602/neurorx.1.1.80] [PMID] [PMCID]
5. Fisher M. New approaches to neuroprotective drug development. Stroke. 2011;42(1 suppl 1):S24-S7. [DOI:10.1161/STROKEAHA.110.592394] [PMID]
6. Kobayashi T, Yanase H, Iwanaga T, Sasaki R, Nagao M. Epididymis is a novel site of erythropoietin production in mouse reproductive organs. Biochemical and biophysical research communications. 2002;296(1):145-51. https://doi.org/10.1016/S0006-291X(02)00832-X [DOI:10.1006/bbrc.1998.9624]
7. Firth AM, Haldane SL. Development of a scale to evaluate postoperative pain in dogs. Journal of the American Veterinary Medical Association. 1999;214(5):651-9. [PMID]
8. Robert CDSEJ, Christensena D. The biology of erythropoietin in the central nervous system and its neurotrophic and neuroprotective potential. Biol Neonate. 2001;79:228-35. [DOI:10.1159/000047097] [PMID]
9. Hashemzadeh KJ. Study of recombinant erythropoietin effects on serum paraoxonase activity, total antioxidant and lipid peroxidation levels in male rats Tabriz: Tabriz University of Medical Sciences; 2010.
10. Anagnostou A, Lee ES, Kessimian N, Levinson R, Steiner M. Erythropoietin has a mitogenic and positive chemotactic effect on endothelial cells. Proceedings of the National Academy of Sciences. 1990;87(15):5978-82. [DOI:10.1073/pnas.87.15.5978]
11. Winn HR. Youmans neurological surgery: WB Saunders Philadelphia; 2004.
12. Davar Altafi MF. Therapeutic effects of intravenous erythropoietin in improving function outcome of intacerebral hemorrhage paitients. Tabriz, Iran: Tabriz University of Medical Sciences; 2010.
13. Shah RR, Tisherman SA. Spinal cord injury. Imaging the ICU Patient: Springer; 2014. p. 377-80. [DOI:10.1007/978-0-85729-781-5_41] [PMID]
14. Westgren N, Levi R. Quality of life and traumatic spinal cord injury. Archives of physical medicine and rehabilitation. 1998;79(11):1433-9. [DOI:10.1016/S0003-9993(98)90240-4]
15. Patel NS, Sharples EJ, Cuzzocrea S, Chatterjee PK, Britti D, Yaqoob MM, et al. Pretreatment with EPO reduces the injury and dysfunction caused by ischemia/reperfusion in the mouse kidney in vivo. Kidney international. 2004;66(3):983-9. [DOI:10.1111/j.1523-1755.2004.00847.x] [PMID]
16. Brines M, Cerami A. Emerging biological roles for erythropoietin in the nervous system. Nature Reviews Neuroscience. 2005;6(6):484-94. [DOI:10.1038/nrn1687] [PMID]
17. Fang X-Q, Fang M, Fan S-W, Gu C-L. Protection of erythropoietin on experimental spinal cord injury by reducing the expression of thrombospondin-1 and transforming growth factor-beta. Chinese medical journal. 2009;122(14):1631-5.
18. Arishima Y, Setoguchi T, Yamaura I, Yone K, Komiya S. Preventive effect of erythropoietin on spinal cord cell apoptosis following acute traumatic injury in rats. Spine. 2006;31(21):2432-8. [DOI:10.1097/01.brs.0000239124.41410.7a] [PMID]
19. Recny MA, Scoble H, Kim Y. Structural characterization of natural human urinary and recombinant DNA-derived erythropoietin. Identification of des-arginine 166 erythropoietin. Journal of Biological Chemistry. 1987;262(35):17156-63. [PMID]

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