Volume 2, Issue 1 (6-2016)                   IrJNS 2016, 2(1): 11-14 | Back to browse issues page


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Yousefzadeh-Chabok S, Alijani B, Emamhadi M, Behzadnia H, Dehghani S, Razzaghi A et al . A Comparison between Therapeutic Effect of Granulocyte Colony-stimulating Factor and Methylprednisolone in Treatment of Patients with Acute Traumatic Spinal Cord Injury. IrJNS. 2016; 2 (1) :11-14
URL: http://irjns.org/article-1-31-en.html
1- Professor , Guilan Road Trauma Research Center
2- Associate Professor , babakalij@gmail.com
3- Associate Professor , Neurosurgery Department
4- Assistant Professor , Guilan Road Trauma Research Center
5- Senior Resident , Poursina Hospital
6- MSc , Guilan Road Trauma Research Center
Abstract:   (1441 Views)

Background & Aim: Spinal cord injury (SCI) is one of the worst kinds of traumatic injuries with remarkable social and economic effects on communities. 

Methods & Materials/Patients: In this prospective randomized clinical trial, 122 patients with traumatic spinal cord injury were admitted to Poursina hospital within 48 hours of injury to compare granulocyte colony stimulating factor (G-CSF) and high-dose methylprednisolone as neuroprotective therapy.

Results: In this research, 122 patients were studied out of whom 62 patients were included in the granulociote colony-stimulating factor (G-CSF) group with a mean age of 40.4, and 60 patients in the methylprednisolone group with an average age of 40.10 years. 55 out of 122 patients (45%) were completely paralyzed (Grade AIS:A) and 67 (55%) were with incomplete spinal injury (Grade AIS:B,C,D). The average American spinal injury association (ASIA) sensory scores in the two groups were similarly compared in the same four time intervals, and p values were 0.7, 0.3, 0.2, and 0.1. They were not statistically significant. 

Conclusion: According to the results, the G-CSF was shown to be beneficial in average ASIA motor and sensory scores in the two groups of male patients at six months of onset of G-CSF treatment (p value=0.04), and average ASIA motor scores improvement in the falls subgroup patients also differed significantly within six months of onset of G-CSF treatment (p value=0.03). A multicentre prospective randomized clinical trial to compare the placebo effect with G-CSF protocol's treatment, and also assessment of the cost benefits of the common medical treatment versus G-CSF are needed. 

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Type of Study: Research | Subject: Gamma Knife Radiosurgery
* Corresponding Author Address: Guilan Road Trauma Research Center

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