Volume 6, Issue 3 (Summer 2020)                   Iran J Neurosurg 2020, 6(3): 143-150 | Back to browse issues page


XML Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Gandhi A, Jain S, Gandhi S, Mishra K, Jain S. Intracranial Mass Lesion Due to Fungal Infection: A Case Series and Review of Literature Series and Review of Literature. Iran J Neurosurg 2020; 6 (3) :143-150
URL: http://irjns.org/article-1-207-en.html
1- Department of Neurosurgery, SMS Medical College, Jaipur, Rajasthan, India.
2- Department of Neurosurgery, SMS Medical College, Jaipur, Rajasthan, India. , simplesogani@gmail.com
3- Department of Pathology, SMS Medical College, Jaipur, Rajasthan, India.
Abstract:   (1938 Views)
Background: Fungal infections of the central nervous system (CNS) usually present as subacute meningitis or intracranial space-occupying lesion with mass effect on surrounding structures and consequent focal neurological deficits. Intracranial fungal granulomas are often misdiagnosed clinically and radiologically as neoplastic lesions. Biopsy of the lesion is the only reliable technique to establish the correct diagnosis as well as to detect the causative fungal species. Voriconazole is a broad-spectrum triazole antifungal agent. It can be given orally and intravenously and has lesser adverse effects.
Methods and Materials: In this article, we report a series of 6 cases of biopsy-proven fungal granuloma with varied clinical and radiological presentations who were given treatment with voriconazole for 6 months and demonstrated favorable response.
Results: Out of 6 patients (4 males and 2 females), 1 was immunocompromised (DM with uncontrolled hyperglycemia). Headache was the most commonly observed symptom. Paranasal sinus and anterior cranial fossa were the most commonly affected site. Four patients received voriconazole therapy for 12 months and 1 received the same for 6 months before showing clinical resolution of disease. There was 1 death in the study group from non-related medical complications.
Conclusion: Our series focuses on the correct diagnosis of fungal granuloma which can be achieved by biopsy and clinical evidence of the efficacy of voriconazole against intracranial fungal granuloma.
Full Text [PDF 2141 kb]   (771 Downloads) |   |   Full Text (HTML)  (869 Views)  
Type of Study: Case Series | Subject: Basic Neurosurgery

Add your comments about this article : Your username or Email:
CAPTCHA

Send email to the article author


Rights and Permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2024 CC BY-NC 4.0 | Iranian Journal of Neurosurgery

Designed & Developed by: Yektaweb