Volume 8, Issue 1 (Continuous publishing 2022)                   Iran J Neurosurg 2022, 8(1): 12-12 | Back to browse issues page

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Shafiei S, Zaheriani M S, Sahfizad M, Ehteshami S, Mosazadeh M, Haddadi K. Evaluation of Vitamin D Neuroprotective Effects on Patients with Traumatic Brain Injury: A Clinical Trial (In press). Iran J Neurosurg. 2022; 8 (1) :12-12
URL: http://irjns.org/article-1-291-en.html
1- Department of Neurosurgery, orthopedic research center, Mazandaran university of Medical sciences, sari, Iran
2- Department of Neurosurgery, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
3- Gastrointestinal Cancer Research Center, Non-communicable Diseases Institute, Mazandaran University of Medical Sciences,sari,Iran
4- Department of Neurosurgery, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran , kavehhaddadi56@gmail.com
Abstract:   (255 Views)
Background and Aim: Traumatic brain injury (TBI) globally constitutes a critical public and socioeconomic health complication. Introducing medications and strategies to treat and improve the prognosis of TBI is crucial. Research suggests the protective effects of vitamin D on the health of brain cells. The present research was conducted to evaluate the neuroprotective effects of vitamin D on patients with TBI presenting to Imam Khomeini Hospital, Sari, Iran.
Methods and Materials/Patients: This randomized clinical trial assigned patients with vitamin D levels of over 30 ng /ml to an intervention group (n=42) and a control group (n=42), who respectively received a single dose (150,000 units) of vitamin D and a placebo upon admission. The Glasgow Coma Score (GCS) and mortality were recorded at the beginning of the study and three months after the final prescription.
Results: The mean GCS score upon admission was obtained as 8.64±2.29 in the vitamin D group and 8.42±2.93 in the placebo group. This score was respectively obtained as 13.50±1.85 and 10.97±2.37 upon discharge, suggesting a significant difference as per the t-test (P=0.04). The mean Glasgow Outcome Score (GOS) upon discharge was obtained as 4.24±1.51 in the intervention group and 4.10±1.40 in the controls. The t-test suggested insignificant differences in the GOS between the two groups upon admission (P=0.823).  After three months, the GOS respectively reaching desirable levels in 49.7% and 62.8% of cases in the placebo and intervention groups showed statistically-significant differences between the two groups (P=0.03).
Conclusion: The present results showed the improving effects of vitamin D on level of consciousness and outcomes in patients with acute TBI. It is recommended that further studies be conducted using larger samples to investigate the effects of other medications, including amantadine and methylphenidate.
Type of Study: Clinical Trial | Subject: Neurotrauma

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