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Faritous S Z, Hashemi Z, Hajiesmaeili M, Morshedizad Z, Bakhshandeh H, Mehrabimahani S. The Effectiveness of Selenium in Oral Nutritional Therapy for Patients with Subarachnoid Hemorrhage. Iran J Neurosurg. 2022; 8 :12-12
URL: http://irjns.org/article-1-302-en.html
1- Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran
2- Department of ICU, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran
3- Shahid Beheshti University of Medical Sciences, Tehran, Iran
4- Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran , zmorshedizad@gmail.com
Abstract:   (344 Views)
Background and Purpose: This study aimed to examine the effects of Selenium added to oral nutritional therapy on the mortality rate and length of hospital stay in patients with subarachnoid hemorrhage admitted for six months to the intensive care unit at Loghman Hakim Hospital, Tehran, Iran.
Materials and Methods: This clinical trial included 100 patients admitted to the intensive care units (ICU) of Loghman Hakim Hospital. These patients were then randomly assigned to intervention or control groups. They were both administered standard oral solutions according to recommended guidelines. Along with the standard nutritional intake, the participants in the intervention group were given 1000µg of Selenium (Selenase-Biosyn, Germany) on the first day of feeding, dissolved in 100mL of normal saline for 30 minutes, followed by 500µg of Selenium daily for 10 days. We screened patients for GCS, and APACHE-II scores, as well as cortisol levels on days 1 and 10 at 8 a.m. in both groups. Analysis of the data was carried out using R statistical packages (R version 4.1.1).
Results: According to the study of patients, the APACHE-II mean score on the 10th day was significantly different between the two groups, and this was also true before the intervention. In terms of mortality rates, there was no significant difference between the control group and the intervention group.
Conclusion: The effects of selenium on other variables were unclear, although mortality rates did not differ significantly between the two groups. Considering the confounding variables through regression analysis, the APACHE-II variable was negatively impacted by selenium, but taking into account the significant effect of age, a definitive conclusion cannot be made. The Cortisol level variable, however, was significantly related to age, as was the GCS variable, which was significantly impacted by sex and age.
     
Type of Study: Research | Subject: Neurotrauma

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