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Iran J Neurosurg 2023, 9 - Continuous Publishing: 0-0 |
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Kargar Jahromi H, Khorram A, Atashpoor S, Jalali M, Kargar Jahromi Z, Mohammadi F, et al . The Effect of Hydroalcoholic Extract of Salep on Pentylenetetrazole-Induced Seizure in Adult Male Rats. Iran J Neurosurg 2023; 9 : 1
URL: http://irjns.org/article-1-332-en.html
URL: http://irjns.org/article-1-332-en.html
Hossein Kargar Jahromi1 
, Arman Khorram2 , Shekofeh Atashpoor3 , Maryam Jalali4 , Zahra Kargar Jahromi1 , Fatemeh Mohammadi5 , Mohammad Amin Serpoosh5 , Najmeh Sadeghi * 6
, Arman Khorram2 , Shekofeh Atashpoor3 , Maryam Jalali4 , Zahra Kargar Jahromi1 , Fatemeh Mohammadi5 , Mohammad Amin Serpoosh5 , Najmeh Sadeghi * 6
1- Research Center for Non-Communicable Diseases, Jahrom University of Medical Sciences, Jahrom, Iran
2- Student Research Committee, Jahrom University of Medical Sciences, Jahrom, Iran
3- Department of Pharmacology, Faculty of Medicine, Jahrom University of Medical Sciences, Jahrom, Iran
4- Research Center for Social Determinants of Health, Jahrom University of Medical Sciences, Jahrom, Iran
5- Department of Basic Sciences, Sirjan School of Medical Sciences, Sirjan, Iran
6- Department of Basic Sciences, Sirjan School of Medical Sciences, Sirjan, Iran ,najmehsa@yahoo.com
2- Student Research Committee, Jahrom University of Medical Sciences, Jahrom, Iran
3- Department of Pharmacology, Faculty of Medicine, Jahrom University of Medical Sciences, Jahrom, Iran
4- Research Center for Social Determinants of Health, Jahrom University of Medical Sciences, Jahrom, Iran
5- Department of Basic Sciences, Sirjan School of Medical Sciences, Sirjan, Iran
6- Department of Basic Sciences, Sirjan School of Medical Sciences, Sirjan, Iran ,
Abstract: (1508 Views)
Background and Aim: Epilepsy as a neurological disorder is characterized by unpredictable and periodic seizures. In the present study, the anticonvulsant effect of different doses of salep hydroalcoholic extract on pentylenetetrazole (PTZ) induced seizures was investigated.
Methods and Materials/Patients: The animal model of seizure was established by the intraperitoneal injection of pentylenetetrazole (PTZ- 85 mg/kg). Hydroalcoholic extract of salep was administered to the animals in 3 doses (80, 160, and 320 mg/kg). The parameters of the onset and duration of tonic-clonic seizure, total seizure time, balance (falling), and jumping during seizure mortality rate were measured. The results were analyzed by ANOVA test at a significant level of p≤0.05.
Results: The results of the current study indicated that salep extract increased the delay in the onset of seizure in the PTZ + extract group in comparison with the PTZ group. The duration of tonic-clonic seizure and the number of falling, jumping, and total seizure times were significantly decreased by salep extract compared to the PTZ group. In the seizure + salep extract, the number and percentage of 24-hour mortality among animals decreased with increasing dosage. All changes were dose-dependent and 320 mg/kg showed the most effect.
Conclusion: Extract of salep can probably have anticonvulsant properties, however, further studies are needed to clarify the exact mechanisms.
Methods and Materials/Patients: The animal model of seizure was established by the intraperitoneal injection of pentylenetetrazole (PTZ- 85 mg/kg). Hydroalcoholic extract of salep was administered to the animals in 3 doses (80, 160, and 320 mg/kg). The parameters of the onset and duration of tonic-clonic seizure, total seizure time, balance (falling), and jumping during seizure mortality rate were measured. The results were analyzed by ANOVA test at a significant level of p≤0.05.
Results: The results of the current study indicated that salep extract increased the delay in the onset of seizure in the PTZ + extract group in comparison with the PTZ group. The duration of tonic-clonic seizure and the number of falling, jumping, and total seizure times were significantly decreased by salep extract compared to the PTZ group. In the seizure + salep extract, the number and percentage of 24-hour mortality among animals decreased with increasing dosage. All changes were dose-dependent and 320 mg/kg showed the most effect.
Conclusion: Extract of salep can probably have anticonvulsant properties, however, further studies are needed to clarify the exact mechanisms.
Article number: 1
Type of Study: Research |
Subject:
Neuroscience
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This is an open access article distributed under the terms of the Creative Commons Attribution License (CC-By-NC), which permits use, distribution, and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
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