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Iran J Neurosurg 2023, 9 - Continuous Publishing: 18-26 |
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Saatian M R, Rostayi M, Jalili E, Ataei S, Poormohammadi A, Farhadian M et al . The Effect of Curcumin on the Recovery of Severe Traumatic Brain Injury: A Double-blind Randomized Controlled Trial. Iran J Neurosurg 2023; 9 : 3
URL: http://irjns.org/article-1-336-en.html
URL: http://irjns.org/article-1-336-en.html
Mohammad Reza Saatian1 
, Masoome Rostayi2 , Ebrahim Jalili * 3, Sara Ataei4 , Ali Poormohammadi5 , Maryam Farhadian6 , Ali Abdoli1
, Masoome Rostayi2 , Ebrahim Jalili * 3, Sara Ataei4 , Ali Poormohammadi5 , Maryam Farhadian6 , Ali Abdoli1
1- Department of Neurosurgery, School of Medicine, Be’sat Hospital, Hamadan University of Medical Sciences, Hamadan, Iran
2- Department of Neurosurgery, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
3- Department of Emergency Medicine, School of Medicine, Be’sat Hospital, Hamadan University of Medical Sciences, Hamadan, Iran ,jalili.dr@gmail.com
4- Department of Clinical Pharmacy and Pharmaceutical Services, Faculty of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran
5- Department of Public Health, Center of Excellence for Occupational Health, Occupational Health and Safety Research Center, School of Public Health, Hamadan University of Medical Sciences Hamadan, Hamadan, Iran
6- Department of Biostatistics, School of Health, Hamadan University of Medical Sciences, Hamadan, Iran
2- Department of Neurosurgery, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
3- Department of Emergency Medicine, School of Medicine, Be’sat Hospital, Hamadan University of Medical Sciences, Hamadan, Iran ,
4- Department of Clinical Pharmacy and Pharmaceutical Services, Faculty of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran
5- Department of Public Health, Center of Excellence for Occupational Health, Occupational Health and Safety Research Center, School of Public Health, Hamadan University of Medical Sciences Hamadan, Hamadan, Iran
6- Department of Biostatistics, School of Health, Hamadan University of Medical Sciences, Hamadan, Iran
Abstract: (1892 Views)
Background and Aim: Traumatic brain injury (TBI) is one of the critical causes of death in trauma patients. In this study, the effect of nanocurcumin on the outcome of severe TBI was investigated for the first time in humans.
Methods and Materials/Patients: This randomized, double-blind, and paralleled controlled study included 128 patients aged from 18 to 70 years with severe brain trauma. Patients were randomly assigned to control group (standard care treatment+placebo) and intervention group
(standard care treatment+oral nanocurcumin). Changes in the level of consciousness, cerebral edema, kidney function, liver enzymes, sodium and potassium electrolytes, and brain function were followed up and compared until 6 months after discharge.
Results: The Mean±SD in the intervention (14.44±31.86 years) and control patients (14.86±33.34 years) had no significant difference (P=0.543). Both groups were similar in terms of gender (P=0.669). The average level of consciousness in the intervention group increased by about 3 units (P=0.004) and more than 2 units (P=0.002) at discharge compared with the control group. By comparing the optimal performance of patients in the first (P=0.389) trimester and second (P=0.309) trimester after discharge, no significant difference was observed between the intervention and control groups. The amount of brain edema caused by severe brain trauma on the seventh day of treatment in the intervention group was lower than that in the control group (P=0.038).
Conclusion: Administrating oral nanocurcumin supplement in patients with severe brain trauma along with their routine treatment is effective in improving brain edema and their level of consciousness without causing coagulation, and liver and kidney complications. These findings are not only statistically significant but also clinically vital.
Methods and Materials/Patients: This randomized, double-blind, and paralleled controlled study included 128 patients aged from 18 to 70 years with severe brain trauma. Patients were randomly assigned to control group (standard care treatment+placebo) and intervention group
(standard care treatment+oral nanocurcumin). Changes in the level of consciousness, cerebral edema, kidney function, liver enzymes, sodium and potassium electrolytes, and brain function were followed up and compared until 6 months after discharge.
Results: The Mean±SD in the intervention (14.44±31.86 years) and control patients (14.86±33.34 years) had no significant difference (P=0.543). Both groups were similar in terms of gender (P=0.669). The average level of consciousness in the intervention group increased by about 3 units (P=0.004) and more than 2 units (P=0.002) at discharge compared with the control group. By comparing the optimal performance of patients in the first (P=0.389) trimester and second (P=0.309) trimester after discharge, no significant difference was observed between the intervention and control groups. The amount of brain edema caused by severe brain trauma on the seventh day of treatment in the intervention group was lower than that in the control group (P=0.038).
Conclusion: Administrating oral nanocurcumin supplement in patients with severe brain trauma along with their routine treatment is effective in improving brain edema and their level of consciousness without causing coagulation, and liver and kidney complications. These findings are not only statistically significant but also clinically vital.
Article number: 3
Type of Study: Clinical Trial |
Subject:
Neurotrauma
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This is an open access article distributed under the terms of the Creative Commons Attribution License (CC-By-NC), which permits use, distribution, and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
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