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Volume 11 - Continuous Publishing
Iran J Neurosurg 2025, 11 - Continuous Publishing: 0-0 |
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Asgari Gashtrodkhani A, Kaveh R, Reihanian Z, Yousefzadeh-Chabok S, Andalib S. Glymphatic System Reconstruction in the Management of Alzheimer’s Disease. Iran J Neurosurg 2025; 11 : 26
URL: http://irjns.org/article-1-531-en.html
URL: http://irjns.org/article-1-531-en.html
Ashkan Asgari Gashtrodkhani1 
, Roxana Kaveh2 , Zoheir Reihanian3 , Shahrokh Yousefzadeh-Chabok4 , Sasan Andalib *5
, Roxana Kaveh2 , Zoheir Reihanian3 , Shahrokh Yousefzadeh-Chabok4 , Sasan Andalib *5
1- School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
2- Guilan Road Trauma Research Center, Trauma Institute, Guilan University of Medical Sciences, Rasht, Iran.
3- Department of Neurosurgery, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
4- Guilan Road Trauma Research Center, Trauma Institute, Guilan University of Medical Sciences, Rasht, Iran. & Department of Neurosurgery, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
5- Guilan Road Trauma Research Center, Trauma Institute, Guilan University of Medical Sciences, Rasht, Iran. & -Research Unit of Neurology, Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark. -Department of Neurology, Odense University Hospital, Odense, Denmark. -Neuroscience Research Center, Trauma Institute, Guilan University of Medical Sciences, Rasht, Iran. ,sasan.andalib@health.sdu.dk
2- Guilan Road Trauma Research Center, Trauma Institute, Guilan University of Medical Sciences, Rasht, Iran.
3- Department of Neurosurgery, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
4- Guilan Road Trauma Research Center, Trauma Institute, Guilan University of Medical Sciences, Rasht, Iran. & Department of Neurosurgery, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
5- Guilan Road Trauma Research Center, Trauma Institute, Guilan University of Medical Sciences, Rasht, Iran. & -Research Unit of Neurology, Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark. -Department of Neurology, Odense University Hospital, Odense, Denmark. -Neuroscience Research Center, Trauma Institute, Guilan University of Medical Sciences, Rasht, Iran. ,
Abstract: (15 Views)
Alzheimer’s disease (AD) is a major public health challenge. The exact cause of AD is unknown, but it is characterized by progressive impairment in cognitive and memory functions and pathological changes in the brain, such as aggregation of two main proteins, amyloid-beta (Aβ) and neurofibrillary tangles (NFTs) of tau. Nonetheless, the pathogenesis of AD appears to be complicated by vascular changes, neuroinflammation, synaptic loss, and impaired clearance of cellular waste products. Currently, the limited efficacy of available treatments underscores the need for alternative therapeutic strategies. The glymphatic system is a paravascular network in the central nervous system, responsible for the removal of cellular waste. The present review discusses the glymphatic system and its reconstructive surgery as a potential treatment approach for AD. Both experimental and human studies have demonstrated the role of the impaired glymphatic system in the pathogenesis of AD by increasing the accumulation of Aβ and tau proteins, thus holding potential as a new target for AD treatment. Moreover, glymphatic system dysfunction can lead to neurodegeneration, cognitive decline, and disease progression. Studies have also shown the potential role of microsurgical lymphatic reconstruction as a possible therapeutic target for AD treatment. Glymphatic system dysfunction may be a possible contributing factor to the pathogenesis and progression of AD. Moreover, glymphatic and meningeal reconstruction microsurgery may have the potential for the treatment of AD.
Article number: 26
Type of Study: Review |
Subject:
Vascular Neurosurgery
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This is an open access article distributed under the terms of the Creative Commons Attribution License (CC-By-NC), which permits use, distribution, and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
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