Search published articles


Showing 4 results for Degeneration

Kaveh Haddadi,
Volume 1, Issue 4 (3-2016)
Abstract

Background & Aim: Low back pain is broadly documented as one of the most widespread pathologies in the advanced domain. Although the reasons of low back pain are uncountable, it has been meaningfully related to intervertebral disc degeneration. Present therapies for Intervertebral Disc (IVD) degeneration such as physical therapy and spinal fusion reduce symptoms' severity, but do not treat the source of degeneration. The use of tissue engineering to treat disc degeneration offers a chance to control the pathological course. New methods are presently being examined and have exposed mixed results. One major way of study has been stem cell injections. We go on to define the course of stem cell-mediated modalities in treatment of degenerative lumbar disc herniation.

Methods & Materials/Patients: Literature search was performed in electronic databases PUBMED and EMBASE by means of Mesh terminologies (Nucleus pulposus, therapeutics, annulus fibrosus, intervertebral disc) and keywords (Degenerative disk disease, Stem Cells, Therapy). Results: The intervertebral disc organization, developing treatments, mesenchymal stem cells, embryonic stem cells, practice in disc degeneration were some sections that were found in analysis for study review design.

Conclusion: Mesenchymal stem cells (MSCs) have revealed potential in small animal models, nonetheless consequences in greater vertebrates have been varied.


Shiva Mashinchi, Zahra Hojjati-Zidashti, Shahrokh Yousefzadeh-Chabok,
Volume 4, Issue 2 (4-2018)
Abstract

Background and Aim: Lumbar disc degeneration is one of the most frequent causes of pain in the lower back, and lack of physical activity, overweight and obesity have been regarded as the most significant factors in its occurrence. The present study was conducted with the aim of evaluation of body mass index, abdominal obesity and physical activity level in patients registered for elective lumbar disc degeneration surgery.
Methods and Materials/Patients: This descriptive-analytical study was conducted on adult patients (20 to 77 years old) candidates for surgery admitted to the Poursina Hospital in Rasht City, Iran in 2016 due to degenerative lumbar vertebrae diseases. After obtaining the patients' consent, their abdominal circumference, weight, and height were measured by the researcher.  The Rapid Assessment of Physical Activity (RAPA) questionnaire was used to assess the level of physical activity of the subjects and questions about professional sports were asked by the researchers. SPSS 16 was used to analyze the study findings. The Chi-square test and Fisher exact test were applied to examine the relationship between qualitative data.
Results: The mean±SD BMI values in males and females were 26.63±4.47 and 28.96±4.45 kg/m2, respectively. Also, the mean±SD values of abdominal circumference in men and women were 99.8±13.35 cm and 107.44±17.58 cm, respectively. The majority of the people (88.5%), including 71.7% of men and 97.6% of women had suboptimal physical activity, and a small percentage of samples (10.8%) reported previous professional exercises 
Conclusion: The present study results indicate the lack of activity level, high BMI and abdominal fat in our patients. Further study is required to investigate the significant relationship between BMI and degenerative disease types

Nima Derakhshan, Arefe Rahimikhorrami,
Volume 6, Issue 2 (4-2020)
Abstract

Background & Importance: Congenital Muscular Torticollis (CMT) is a common cause of torticollis in children. Despite the easy diagnosis, rare cases may be neglected and untreated during the management of the patients, which can not only impose cosmetic problems for them but also affect the cervical spine with accelerated degeneration. Most patients with CMT can be managed non-surgically with medical and physical therapies but surgery is indicated in some cases when non-surgical attempts are unsuccessful.
Case Presentation: Herein, we are reporting a 16-year-old female with neglected CMT, and neck pain secondary to severe degenerative changes. We believe that neglected and untreated CMT cases may present with accelerated spine degeneration and surgical intervention should be considered promptly to reverse this process.
Conclusion: Surgical intervention not only produces good cosmetic results but also reverses the degeneration process and protects the patient from disabling deformities later in life.

Shiva Mashinchi, Shahrokh Yousefzadeh-Chabok, Mesbah Dibavand,
Volume 6, Issue 3 (7-2020)
Abstract

Background and Aim: Previous studies have reported the important effect of age, sex, heredity, and occupational status on intervertebral degenerative dick diseases, which are among the most important causes of low back pain. However, their results are not always so conclusive. This study was performed to investigate the demographic characteristics and family history of lumbar problems in patients with lumbar degenerative dick diseases due to causes other than acute trauma.
Methods and Materials/Patients: This cross-sectional descriptive study included patients without acute trauma who were candidates for surgery of lumbar degenerative dick diseases from 2017 to 2018 in the only state hospital admitting these patients in Rasht, Iran. The data related to the disease were obtained from the patients' medical records. Their demographic characteristics and family history of lumbar vertebrae diseases in their relatives were collected using a researcher-made questionnaire through face-to-face interview by the researcher. The data were analyzed using SPSS (Version 16). Descriptive statistics and the chi-square test were conducted at a significance level of 0.05.
Results: More than half of the patients were in their 4th to 6th decades of life, and the number of men was 1.8 times as women. The frequency of herniated discs was more than that of both spinal canal stenosis and spondylolisthesis, and most people had no history of low back trauma. The duration of disease in 73% of the patients was more than 1 year and the mean duration was about 4.5 years. More than half of the patients reported problems with the lumbar vertebrae in at least 1 of their first-degree relatives. About one-third of the patients reported a history of vertebrae surgery in their first-degree relatives and the maximum number of reported surgeries in 1 family was 5. Most of the patients were low-literate and illiterate, and about one-third of the patients were workers/farmers. More than one-third of them were housewives and the number of patients working in administrative and driving jobs was very low. There was no significant relationship between study variables and the type of degenerative problems of the lumbar vertebrae.
Conclusion: These findings showed similarities with previous studies in terms of age groups, occupational status, and a history of family lumbar problems in patients with lumbar degenerative disc diseases.
 


Page 1 from 1     

© 2025 CC BY-NC 4.0 | Iranian Journal of Neurosurgery

Designed & Developed by: Yektaweb