Volume 5, Issue 3 And 4 (Summer & Autumn 2019)                   Iran J Neurosurg 2019, 5(3 And 4): 117-124 | Back to browse issues page


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Masoudi M S, Hadi N, Ghaffarpasand F, Askarpour M, Ershadi F, Sadeghpour T. Risk Factors of Neural Tube Defects in a Sample of Iranian Population From Southern Iran: A Hospital-based InvestigationIranian Population From Southern Iran: A Hospital-based Investigation. Iran J Neurosurg. 2019; 5 (3 and 4) :117-124
URL: http://irjns.org/article-1-160-en.html
1- Department of Neurosurgery, Shiraz University of Medical Sciences, Shiraz, Iran
2- Department of Community Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
3- Neuromodulation and Pain Research Center, Shiraz University of Medical Sciences, Shiraz, Iran , fariborz.ghaffarpasand@gmail.com
4- Student Research Committee, Department of Community Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
5- Department of Pediatric Neurosurgery, Namazi Hospital, Shiraz, Iran
Abstract:   (1822 Views)

Background and Aim: The risk factors of the Neural Tube Defects (NTD) have been previously described but there are ethnic and geographical variations. Data from the Iranian population is still scarce. The objective of the current study was to investigate the NTDs risk factors in a large sample
of Iranian patients admitted to a single center. 
Methods and Materials/Patients: This case-control study was performed within five years from 2012 to 2017 in Namazi Hospital of Shiraz, a tertiary referral center for neonatal anomalies in the south of Iran. One hundred newborns with NTDs were included in the study as the case group and 200 healthy newborns as the control group. We recorded the baseline characteristics including the maternal variables (age, weight, height, previous pregnancy and gravidity, gestational age), newborn information (birth weight, clinical diagnosis, clinical findings in the examination, and clinical findings in radiologic test) and medical history of the perinatal period.
Results: The baseline characteristics of the mothers were matched in both groups. NTDs were associated with lower folic acid intake during pregnancy (66% vs. 78%; P=0.030; OR 95% CI=1.82) and before pregnancy (P=0.002; OR95% CI=2.36). The prevalence of NTD was significantly higher in patients who lived in hot climates (P=0.001).
Conclusion: Taking adequate folic acid supplements before and during pregnancy can
reduce the risk of NTDs in the Iranian population. Hot climate zones were associated with an
increased risk of NTDs in Iran.

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Type of Study: Research | Subject: Basic Neurosurgery

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