Volume 7, Issue 4 (Autumn 2021)                   Iran J Neurosurg 2021, 7(4): 1-1 | Back to browse issues page

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Hoseinpourfard M, Nasehi M, Zarrindast M, Izadi M, Nami M. Evaluation of Pain Tolerance Threshold Following Anti TNF-α after Induction REM Sleep Deprivation in a Male Wistar Rat Model (In press). Iran J Neurosurg. 2021; 7 (4) :1-1
URL: http://irjns.org/article-1-278-en.html
1- 1. Institute for Cognitive Science Studies, Tehran, Iran.; 2. Neuroscience Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran. , hpf.javad@gmail.com
2- Institute for Cognitive Science Studies, Tehran, Iran.
3- International Travel Medicine and Global Health, Neuroscience Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
4- Neuroscience Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Abstract:   (208 Views)
Background and Aim: Tumor Necrose Factor-alpha (TNF-α) changes by REM sleep deprivation. Some believe that TNF-α is a biomarker in the deprivation of REM sleep. The patients with insomnia could be better after using Anti TNF-α or Infliximab (IFX), on the other hand, IFX effects on Patient Tolerance Threshold (PTT). Trying to manage the hospital inpatients’ pain is one of the common aims specially for intensive care unit patients.
Methods and Materials: An experimental study with 72 male Wistar rats in 9 groups that each of groups include 8 rats and approved according to the ethics code in ethics committee of Tehran medical sciences university (CNS.Protocol-ICSS-940816). IFX was administered and it showed the time of the latency changed as PTT.
Results: A significant difference between saline and IFX 0.2 mg/kg (F2 = 8.363, (P = <0.001)) in the time of latency observed.
Conclusion: REM sleep deprivation effects on TNF-α and IFX change the PTT in a Wistar rat model. So, these findings could be considered complex for patients and must to manage.
Type of Study: Research | Subject: Neuroscience

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